Role of hypothermia in the production of gastric ulcers in a rat spinal cord transection model

Digestive Diseases and Sciences
H H Sigman, A Gillich

Abstract

An association between hypothermia and gastric ulceration has been reported in rats in cervical cord section and in restraint models. The present study was designed to determine this relationship in cervical and in lumbar cord sectioned Sprague-Dawley rats. Ambient temperatures were varied by placing the sectioned animals in a room-temperature (23 degrees), incubator (28 degrees), or cold-room (4 degrees) environment for 8 hr. Rectal temperatures were recorded at the beginning and end of all experimental conditions. The endpoint of each study was the presence or absence of ulcers on naked eye examination. The length of each ulcer was measured and the lengths were totaled for each stomach. Cervical section rats became hypothermic at room temperature and developed extensive linear ulcerations of the glandular stomachs. A warm environment reduced both the decrement in core temperature and the degree of ulceration. Lumbar section rats only became hypothermic when exposed to cold and then developed significant ulcers. Hypothermia plays an important role in ulcerogenesis, but other factors are also important since not all the hypothermic rats developed ulcers and exposure of sham-operated rats to cold led to occasional pinpoint ulcer...Continue Reading

References

Oct 27, 1979·Lancet·S Szabo
Mar 1, 1970·The American Journal of Digestive Diseases·S SethbhakdiJ L Roth
Apr 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·E C Senay, R J Levine
Aug 1, 1957·The American Journal of Physiology·A C HSIEHG GRAY
Aug 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·D A BRODIE, L S VALITSKI
Feb 1, 1965·JAMA : the Journal of the American Medical Association·D M NICOLOFFO H WANGENSTEEN

❮ Previous
Next ❯

Citations

Apr 1, 1987·Digestive Diseases and Sciences·D G MacLellanK J Hardy
Oct 22, 2005·Digestive Diseases and Sciences·George M Strain, Ron D Waldrop
Dec 25, 2013·Journal of Forensic and Legal Medicine·Chong ZhouRoger W Byard
Apr 2, 1998·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·R D Waldrop, G M Strain
Apr 2, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Emily M BradfordGary E Shull
Jun 1, 1986·The Australian and New Zealand Journal of Surgery·D G MacLellanK J Hardy
Apr 1, 1989·Journal of Neurosurgery·M MeglioG F Rossi
Jan 1, 1986·Journal of Neurosurgery·J BrosetaV Joanes
Nov 1, 1988·Journal of Clinical Pharmacology·L J LipkaJ Roberts

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.