Abstract
Hypoxia is a potent stimulus for inflammation and remodeling. Hypoxia develops in chronic sinusitis as shown via tissue oxygen concentrations and colonization with obligate anaerobes. This hypoxia reflects occlusion of the sinus ostia and thereby failure of transepithelial oxygenation, nonvascularized exudates, and the tendency of inflammatory hyperplasia to exceed neovascularization. Hypoxia-induced transcription factors are responsible for transcription of numerous inflammatory cytokines and growth factors, including vascular endothelial growth factor, CXCL8, CCL11, transforming growth factor-beta, inducible nitric oxide synthase, as well as matrix remodeling proteins such as procollagen and matrix metalloproteinases. Many diseases, such as asthma, share the tendency to afflict respiratory epithelium of the lower (bronchi) and upper (sinus) airway. Although the histopathology and inflammation of asthma and its associated sinusitis share many features, aggressive fibrosis, polyp formation and intense hyperplasia are not features of asthma, a disease seldom associated with significant chronic hypoxia. In contrast, fibrosis is a cardinal feature of hypoxic diseases of the lungs such as interstitial lung diseases and primary pulm...Continue Reading
References
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·R P Schleimer, B S Bochner
Feb 1, 1996·The Laryngoscope·T NorlanderB Carlsöö
Jul 1, 1997·The Laryngoscope·Q P WangA Coste
Jan 8, 1999·Acta Oto-laryngologica. Supplementum·T NakagawaZ Takeda
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·P ChanezJ Bousquet
Jun 3, 1999·Nature·P H MaxwellP J Ratcliffe
Feb 12, 2000·The Journal of Allergy and Clinical Immunology·P ChristodoulopoulosQ Hamid
Apr 10, 2002·The Journal of Allergy and Clinical Immunology·Anneke ten BrinkeElisabeth H Bel
Apr 13, 2002·Advances in Experimental Medicine and Biology·N C Gonzalez, J G Wood
Jun 12, 2003·Acta Oto-laryngologica·Shoji MatsuneYuichi Kurono
Aug 16, 2003·American Journal of Respiratory Cell and Molecular Biology·John W SteinkeLarry Borish
Oct 3, 2003·The Journal of Clinical Investigation·Patrick Flood-PageA Barry Kay
Oct 17, 2003·Cytokine·Eleni PapakonstantinouGeorge Karakiulakis
Dec 4, 2003·Molecular and Cellular Biology·Cheng-Jun HuM Celeste Simon
Feb 18, 2004·The Journal of Clinical Investigation·Jae Youn ChoDavid H Broide
Jan 15, 2005·Journal of Applied Physiology·Kurt R StenmarkMaria G Frid
Jan 27, 2005·Journal of Cellular Physiology·H LeufgenM Roth
Jun 30, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kimberly MasciaJohn W Steinke
Jul 26, 2005·Auris, Nasus, Larynx·Dong SunYuichi Kurono
Oct 15, 2005·Journal of Applied Physiology·Yiu-Fai ChenSuzanne Oparil
Jan 18, 2006·Respiratory Research·Laura BottoPaola Palestini
Sep 30, 2006·Circulation Research·Kurt R StenmarkMaria G Frid
Oct 10, 2006·Current Allergy and Asthma Reports·John W Steinke
Nov 14, 2006·The Journal of Biological Chemistry·George KarakiulakisMichael Roth
Jan 9, 2007·Current Opinion in Genetics & Development·John D Gordan, M Celeste Simon
Mar 6, 2007·The Laryngoscope·S Brandon EarlyJohn W Steinke
Apr 12, 2007·Cancer Science·Tao WangMasashi Fukayama
Apr 20, 2007·Biochimica Et Biophysica Acta·M IrigoyenA Rouzaut
Apr 28, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·John H KrouseMaria C Veling
Sep 4, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Richard M Rosenfeld
Citations
Sep 18, 2013·Cardiovascular Research·Dewei ChenYuqi Gao
Feb 11, 2012·American Journal of Respiratory and Critical Care Medicine·Hyun-Woo ShinJong-Wan Park
Oct 9, 2012·The Journal of Clinical Investigation·Robert J LeeNoam A Cohen
Jul 25, 2012·Respiratory Research·Guillermina J Baay-GuzmanSara Huerta-Yepez
May 21, 2014·PloS One·Yoon-Ju KimChang-Hoon Kim
Jan 31, 2009·American Journal of Rhinology·Spencer C PayneJohn W Steinke
Nov 3, 2015·Bioscience, Biotechnology, and Biochemistry·Mauro PratoCaterina Guiot
Jun 28, 2011·The Journal of Allergy and Clinical Immunology·Spencer C PayneJohn W Steinke
Oct 26, 2011·The Laryngoscope·Angela BlountBradford A Woodworth
May 7, 2015·The Laryngoscope·Bradford A Woodworth
Jul 10, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Seong Ho ChoPhilippe Gevaert
Sep 15, 2016·Mucosal Immunology·H J MinC-H Kim
Apr 8, 2017·Nutrition Research and Practice·Nam Yong DoJi-Eun Lee
Aug 1, 2012·International Archives of Allergy and Immunology·You-Mi MoonHeung-Man Lee
Sep 24, 2016·American Journal of Rhinology & Allergy·Benjamin M Hariri, Noam A Cohen
Jun 30, 2011·American Journal of Rhinology & Allergy·Chia-Tung ShunChia-Ming Liu
Sep 1, 2017·Journal of Medical Microbiology·Gavin J HumphreysAndrew J McBain
Apr 14, 2010·Current Opinion in Allergy and Clinical Immunology·Myriam Vogtel, Alexandra Michels
Jan 26, 2018·BMB Reports·Hyung-Ju Cho, Chang-Hoon Kim
Apr 25, 2018·Microbiome·Charlotte De RudderTom Van de Wiele
Sep 29, 2020·Frontiers in Cellular and Infection Microbiology·Massimiliano MarazzatoMaria Pia Conte
Jun 10, 2017·American Journal of Respiratory Cell and Molecular Biology·Hyun-Ah SongChang-Hoon Kim
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou
Aug 28, 2021·International Forum of Allergy & Rhinology·Dong-Jin LimDo-Yeon Cho
Dec 17, 2008·Current Opinion in Pulmonary Medicine
Dec 25, 2008·Current Opinion in Allergy and Clinical Immunology