PMID: 15240709Jul 9, 2004Paper

Role of IFN regulatory factor-1 and IL-12 in immunological resistance to pathogenesis of N-methyl-N-nitrosourea-induced T lymphoma

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jianguo LiuXiaojing Ma

Abstract

IFN regulatory factor-1 (IRF-1) is a critical effector molecule in IFN signaling and acts as a tumor suppressor and tumor susceptibility gene. IL-12 is a key factor in the induction of innate resistance and generation of Th1 cells and CTL. Our recent study has revealed an intimate relationship between IRF-1 and IL-12 in that IRF-1 regulates the production of IL-12 by selectively controlling transcriptional activation of IL-12 p35 gene. In this work, we find that IRF-1-deficient mice are highly susceptible to N-methyl-N-nitrosourea (MNU)-induced T lymphomas. This susceptibility is associated with strong defects in the expression of IL-12, lymphotoxin (LT)beta, and IFN-gamma. Consistently, IL-12 p35(-/-), IFN-gamma(-/-), and LTbeta(-/-) mice are also highly vulnerable to MNU-induced carcinogenesis. Administration of rIL-12 to IRF-1(-/-) mice restores normal expression of LTbeta and IFN-gamma, and significantly enhances the ability of IRF-1(-/-) mice to resist MNU-induced pathogenesis. This strongly suggests an IRF-1/IL-12/IFN-gamma regulatory axis in tumor surveillance. By DNA microarray analysis, we comprehensively identify differences and patterns in gene expression in splenocytes of wild-type (WT) vs IRF-1(-/-) mice challenged...Continue Reading

References

Jan 1, 1967·Advances in Cancer Research·P N Magee, J M Barnes
Oct 1, 1993·The Journal of Experimental Medicine·M J BrundaM K Gately
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y NoguchiL J Old
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·I M WangK Ozato
Mar 13, 2001·Annual Review of Immunology·T TaniguchiN Tanaka
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T OhtekiS Koyasu
Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J KolletT M Petro
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C HölscherF Brombacher
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Laura BelladonnaPaolo Puccetti
Sep 19, 2002·British Journal of Cancer·D OosterhoffW R Gerritsen
Oct 31, 2002·Nature Immunology·Gavin P DunnRobert D Schreiber
Nov 6, 2002·The Journal of Biological Chemistry·Sudeepta AggarwalAustin L Gurney
Nov 28, 2002·Nature Genetics·David L GerholdSteven R Gullans
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saho MaruyamaYoshihiro Asano
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chia-Hui LoMi-Hua Tao
Dec 10, 2003·The Journal of Experimental Medicine·Craig A MurphyDaniel J Cua

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Citations

Aug 4, 2012·International Journal of Cancer. Journal International Du Cancer·Marieke F FransenCornelis J M Melief
Sep 6, 2014·Cell Death and Differentiation·S TuguesB Becher
Mar 25, 2006·Future Oncology·Pier-Luigi LolliniPatrizia Nanni
Jul 10, 2010·Journal of Biomedicine & Biotechnology·Mathijs P Bergman, Mario M D'Elios
May 4, 2007·The Journal of Clinical Investigation·Jeremy B Swann, Mark J Smyth
Oct 7, 2008·Oncogene·N ChaputL Zitvogel
Jan 12, 2011·Annual Review of Immunology·Matthew D VeselyMark J Smyth
Aug 19, 2017·International Journal of Molecular Sciences·Anna KakehashiHideki Wanibuchi
Apr 9, 2020·Frontiers in Immunology·Lara GibelliniAndrea Cossarizza
Sep 9, 2011·Cancer Research·Antje KsienzykAndrea Kröger
Jul 3, 2021·International Journal of Molecular Sciences·Elena Shklovskaya, Helen Rizos

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