Role of IgE in eosinophilic otitis media

Allergology International : Official Journal of the Japanese Society of Allergology
Yukiko Iino

Abstract

Eosinophilic otitis media (EOM) is an intractable otitis media characterized by the presence of a highly viscous yellow effusion containing eosinophils. It mainly occurs in patients with bronchial asthma and is resistant to conventional treatments for otitis media. Here we discuss the role of IgE in the pathogenesis of EOM. In middle ear effusion, a significantly higher IgE level was detected in EOM patients than in control patients with common otitis media with effusion. This IgE level was significantly higher (about 10 fold) than the serum IgE level. In addition, many IgE-immunopositive cells were found in the middle ear mucosa. The IgE staining was mainly observed on mast cell surfaces, but also partially in the cytoplasm of cells that appeared to be plasma cells. These results suggested that IgE is produced locally in the middle ear mucosa. The existence of high-level IgE may exacerbate eosinophilic inflammation in the middle ear. One of the most distinct characteristics of EOM is the high incidence of sensory hearing loss independent of age. High-tone hearing loss is more frequently found and more severe in EOM patients than in control patients with common chronic otitis media. The concentration of IgE in middle ear effusi...Continue Reading

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Citations

Apr 21, 2012·International Journal of Otolaryngology·Yoshihisa NakamuraJizhen Lin
Aug 3, 2013·Pediatric Clinics of North America·Elton Lambert, Soham Roy
Nov 8, 2015·Current Allergy and Asthma Reports·Hiromi KanazawaYukiko Iino
Apr 25, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Nobuo OhtaKenji Izuhara
Jul 11, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Atsushi FukudaAkihiro Homma
Aug 4, 2020·Ear, Nose, & Throat Journal·Lalee VargheseAnand Job
Oct 19, 2017·Acta Oto-laryngologica·Issam SalibaAlain Bestavros
Apr 30, 2017·Current Allergy and Asthma Reports·Shigeharu UekiMakoto Hirokawa
Jan 11, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Kevin Chow, Maura K Cosetti
Oct 22, 2018·Current Allergy and Asthma Reports·Rachel E Roditi, Jennifer J Shin

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