Role of IL-12B promoter polymorphism in Adamantiades-Behcet's disease susceptibility: An involvement of Th1 immunoreactivity against Streptococcus Sanguinis antigen

The Journal of Investigative Dermatology
Hirokatsu YanagihoriFumio Kaneko

Abstract

Adamantiades-Behcet's disease (ABD) is a chronic inflammatory multisystem disorder. Although the precise etiology is unclear, high prevalence of human leukocyte antigen (HLA)-B51 predisposition and predominantly involved T-helper type 1 cells (Th1)-type proinflammatory cytokines and extrinsic Streptococcal infection suggest a substantial association with an immunogenetic basis and strengthens the hypothesis that IL-12, a potent inducer of Th-1 immune reaction, is a putative candidate in its pathogenesis. These clinicopathological findings led us to examine interleukin 12 p40 (IL-12B) promoter polymorphism, for which the 4-base pair (bp) heterozygous insertion has been shown to affect the gene transcription and subsequent protein production. We analyzed IL-12B promoter genotypes in 194 Japanese subjects (92 with ABD and 102 normal controls) by PCR-based restriction enzyme digestion. The frequency of the insertion heterozygosity was significantly higher in patients than in controls (49/92, 53.3% vs 39/102, 38.2%, respectively). Comparing these with HLA haplotype data, this trend was more significant in HLA-B51-negative patients (29/42, 69.0% vs 20/50, 40.0%; P = 0.005). As assessed by semiquantitative reverse transcription-PCR an...Continue Reading

References

Nov 1, 1995·The Journal of Experimental Medicine·M F NeurathW Strober
Jul 1, 1993·Immunology Today·G Trinchieri
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·N MizukiH Inoko
Apr 23, 2004·The Journal of Investigative Dermatology·Nicolle H R LitjensPeter H Nibbering
Aug 24, 2004·American Journal of Human Genetics·Adrienne G RandolphScott T Weiss

❮ Previous
Next ❯

Citations

Mar 5, 2009·Rheumatology·Cristina C BeliznaYehuda Shoenfeld
Nov 6, 2010·Clinical & Developmental Immunology·Fumio KanekoKeiji Oguma
Oct 21, 2011·Pathology Research International·Tamer İrfan Kaya
Nov 22, 2011·Best Practice & Research. Clinical Rheumatology·Gulen Hatemi, Hasan Yazici
Aug 7, 2014·Journal of Ophthalmic Inflammation and Infection·Joanne Yw NgChi-Pui Pang
Jan 31, 2013·International Reviews of Immunology·James T Rosenbaum, Hyun Woong Kim
Jan 1, 2010·Dermato-endocrinology·Sabine Fimmel, Christos C Zouboulis
Mar 4, 2014·Genetics Research International·Fumio KanekoKoichiro Nakamura
Aug 20, 2008·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Abuzer GündüzAdnan Seyrek
Jan 11, 2007·Clinical Rheumatology·Gamze AlayliTayyar Cantürk
Feb 19, 2008·Current Opinion in Rheumatology·Ilan Krause, Abraham Weinberger
Oct 24, 2019·Anais Brasileiros De Dermatologia·Mitra AtaeiZohreh Jadali
Nov 17, 2020·Frontiers in Immunology·Sandro F PerazzioAlexandre W S de Souza
Jan 1, 2019·Anais Brasileiros De Dermatologia·Mitra AtaeiZohreh Jadali
Feb 19, 2008·Current Opinion in Rheumatology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.