Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp

Allergy, Asthma & Immunology Research
Gwanghui RyuJi Hun Mo

Abstract

Th17-associated inflammation is increased in chronic rhinosinusitis with nasal polyp (CRSwNP), and is associated with disease severity and steroid resistance. Overexpressed interleukin (IL)-17A affects CRSwNP by tissue remodeling, eosinophilic accumulation, and neutrophilic infiltration. We aimed to identify the role of IL-17A in CRSwNP and to evaluate the effects of anti-IL-17A blocking antibody on nasal polyp (NP) formation using a murine NP model. Moreover, we sought to investigate whether the inhibition of mechanistic target of the rapamycin (mTOR) signal pathway could suppress IL-17A expression and NP formation. Human sinonasal tissues from control subjects and patients with chronic rhinosinusitis (CRS) were analyzed using immunohistochemistry (IHC) and immunofluorescence staining. The effects of IL-17A neutralizing antibody and rapamycin were evaluated in a murine NP model. Mouse samples were analyzed using IHC, quantitative real-time polymerase chain reaction, and enzyme-linked immunosorbent assay. IL-17A⁺ inflammatory cells were significantly increased in number in NP from patients with CRSwNP compared to that in uncinate process tissues from control subjects and patients with CRS without NP or CRSwNP. CD68⁺ M1 macropha...Continue Reading

References

May 20, 2005·American Journal of Respiratory Cell and Molecular Biology·Svetlana SergejevaAnders Lindén
Mar 22, 2007·Nature Immunology·Estelle BettelliVijay K Kuchroo
Jul 20, 2007·The Journal of Experimental Medicine·Francesco AnnunziatoSergio Romagnani
Nov 28, 2007·The Journal of Experimental Medicine·Lisa C ZabaJames G Krueger
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura McKinleyJay K Kolls
Sep 23, 2008·The Journal of Allergy and Clinical Immunology·Nan ZhangClaus Bachert
Oct 22, 2009·International Archives of Allergy and Immunology·Yang ZhaoWei Guo
Jul 14, 2010·The Journal of Allergy and Clinical Immunology·Seiichiro MakiharaKazunori Nishizaki
Oct 22, 2010·Nature·Kamran GhoreschiJohn J O'Shea
Nov 19, 2010·The Journal of Investigative Dermatology·Andrea ChiricozziJames G Krueger
Dec 22, 2011·American Journal of Rhinology & Allergy·Xiao-Dan JiangDong-Dong Zhu
Feb 11, 2012·American Journal of Respiratory and Critical Care Medicine·Hyun-Woo ShinJong-Wan Park
Mar 30, 2012·The New England Journal of Medicine·Craig LeonardiSubhashis Banerjee
Apr 5, 2013·Annals of the New York Academy of Sciences·Shigenori NagaiShigeo Koyasu
Jun 5, 2013·The Journal of Investigative Dermatology·Claire Q F WangJames G Krueger
Oct 26, 2013·International Archives of Allergy and Immunology·Robert LinkeBarbara Wollenberg
Nov 10, 2013·American Journal of Respiratory and Critical Care Medicine·William W BusseShao-Lee Lin
Dec 24, 2014·International Forum of Allergy & Rhinology·Jeff Yi-Fu ChenLing-Feng Wang
Mar 11, 2015·International Forum of Allergy & Rhinology·Sung-Lyong HongChae-Seo Rhee
Apr 4, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Atsushi Kato
Sep 1, 2013·Emerging Microbes & Infections·Wei Jin, Chen Dong
Dec 10, 2015·Expert Review of Clinical Pharmacology·Tarannum JaleelBoni Elewski
Mar 8, 2016·The Journal of Allergy and Clinical Immunology·Peter TomassenClaus Bachert
Apr 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Feidi ChenYingzi Cong
Aug 22, 2016·The Journal of Allergy and Clinical Immunology·Xiangdong WangClaus Bachert
Nov 26, 2016·Thorax·Dong-Kyu KimDae Woo Kim
Apr 22, 2017·Current Allergy and Asthma Reports·Gretchen M OakleyValerie J Lund
May 28, 2017·International Immunopharmacology·Said Ahmad ShahKazuhiko Takeuchi
Dec 20, 2017·Oncotarget·Qian XiuDongdong Zhu
Dec 24, 2017·The Journal of Allergy and Clinical Immunology·Hai WangZheng Liu
Jul 5, 2019·The Journal of Allergy and Clinical Immunology·Min WangClaus Bachert
Aug 10, 2019·Clinical and Experimental Otorhinolaryngology·Hai WangZheng Liu
Aug 31, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hui ZhangXiaoning Zhong
Oct 3, 2019·Clinical and Experimental Otorhinolaryngology·Dae Woo Kim

❮ Previous
Next ❯

Citations

Aug 18, 2021·The Journal of Allergy and Clinical Immunology·Min-Seok RhaEui-Cheol Shin
Nov 3, 2021·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Jae-Sung NamHyung-Ju Cho

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
PCR
enzyme-linked immunosorbent assay

Software Mentioned

GraphPad
Graphpad prism
Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.