Role of Imaging in Response Assessment and Individualised Treatment for Sarcomas

Clinical Oncology : a Journal of the Royal College of Radiologists
H Choi

Abstract

The first systematic response evaluation criteria were established by WHO, based on the tumor size changes shortly after the computed tomography (CT) technique became available to the daily practice. RECIST, a simplified version of WHO criteria, and its newer version, RECIST1.1 are the currently available international response evaluation criteria in solid tumors and remains based on tumor size changes. While the introduction of molecularly targeted drugs has significantly improved the survival in patient with sarcomas, the evaluation of tumor response has become more complicated. Increasing number of studies have reported the lack of shrinkage in responding tumors and raised concerns of significant underestimation of responses using RECIST. The first such observation was made on gastrointestinal stromal tumor (GIST) treated with imatinib. In GISTs responding to imatinib, the degree of contrast enhancement on CT typically decreases significantly compared with the baseline, and, regardless of whether tumors shrink, heterogeneous hyperattenuating tumors become homogeneous hypoattenuating tumors with a smaller enhancing solid component. In current oncology practice, CT is a widely accepted method of evaluating tumor response. CT i...Continue Reading

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Citations

May 30, 2017·Clinical Oncology : a Journal of the Royal College of Radiologists·H HatcherT Ajithkumar
Jun 7, 2017·Clinical Oncology : a Journal of the Royal College of Radiologists·T V Ajithkumar, H Hatcher
Aug 25, 2018·The Oncologist·Rebecca C ArendThomas J Herzog
May 16, 2018·World Journal of Gastroenterology : WJG·Juan Manuel Sanchez-HidalgoJavier Briceño-Delgado
Jul 4, 2020·Revista española de medicina nuclear e imagen molecular·B Rodríguez-AlfonsoJ Orcajo Rincón
Jun 10, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michael SaerensLore Lapeire

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