Role of immune cells in the removal of deleterious senescent cells

Immunity & Ageing : I & a
Abhijit KaleJ Campisi

Abstract

Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The senescence arrest prevents the development of cancer, and the SASP can promote tissue repair. Recent data suggest that the prolonged presence of senescent cells, and especially the SASP, could be deleterious, and their beneficial effects early in life can become maladaptive such that they drive aging phenotypes and pathologies late in life. It is therefore important to develop strategies to eliminate senescent cells. There are currently under development or approved several immune cell-based therapies for cancer, which could be redesigned to target senescent cells. This review focuses on this possible use of immune cells and discusses how current cell-based therapies could be used for senescent cell removal.

References

May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P H HartJ A Hamilton
May 15, 1972·International Journal of Cancer. Journal International Du Cancer·E B RosenbergJ R Wunderlich
Jan 1, 1996·Annual Review of Immunology·A MorettaL Moretta
Jan 1, 1997·Annual Review of Immunology·J MacMickingC Nathan
Jan 1, 1997·Annual Review of Immunology·U BoehmJ C Howard
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C D MillsA M Hill
Oct 31, 2001·Trends in Cell Biology·J Campisi
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M HesseT A Wynn
Mar 26, 2003·Biochemical Society Transactions·C Franceschi, M Bonafè
Feb 4, 2005·The Journal of Clinical Investigation·Ramón Bataller, David A Brenner
Apr 6, 2005·The Journal of Experimental Medicine·Sumati Rajagopalan, Eric O Long
Apr 19, 2005·The International Journal of Biochemistry & Cell Biology·Jianming DuanTanjun Tong
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Nov 25, 2006·Nature Reviews. Immunology·Ilia VoskoboinikJoseph A Trapani
Dec 1, 2006·Immunity & Ageing : I & a·Shivani M ChidrawarPaul A H Moss
Aug 2, 2007·Nature Reviews. Molecular Cell Biology·Judith Campisi, Fabrizio d'Adda di Fagagna
Jun 25, 2008·Nature Reviews. Cancer·Fabrizio d'Adda di Fagagna
Aug 30, 2008·Cell·Valery KrizhanovskyScott W Lowe
Jan 19, 2010·Annual Review of Pathology·Jean-Philippe CoppéJudith Campisi
Oct 21, 2010·Annals of the New York Academy of Sciences·Dror MevorachInna Verbovetski-Reiner
Nov 26, 2010·Current Opinion in Genetics & Development·Judith Campisi
Nov 13, 2012·Annual Review of Physiology·Judith Campisi
Apr 9, 2013·Cell·Amaia LujambioScott W Lowe
Apr 13, 2013·Cell Death and Differentiation·C J ChanL Martinet
Jun 19, 2013·Nature Cell Biology·Juan Carlos AcostaJesús Gil
Sep 18, 2013·The Journal of Experimental Medicine·Alexandre IannelloDavid H Raulet
Nov 19, 2013·Cell·Daniel Muñoz-EspínManuel Serrano
May 17, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Claudio Franceschi, Judith Campisi
May 23, 2014·Nature·Jan M van Deursen
Jun 24, 2014·Nature Reviews. Molecular Cell Biology·Daniel Muñoz-Espín, Manuel Serrano
Dec 17, 2014·Developmental Cell·Marco DemariaJudith Campisi

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Citations

Nov 10, 2020·Aging Cell·Axel KowaldThomas B L Kirkwood
Dec 23, 2020·Open Biology·Sonia S Elder, Elaine Emmerson
Jan 14, 2021·Immunity·Christina D Camell
Jan 15, 2021·Immunity & Ageing : I & a·L DuongC Jackaman
Dec 31, 2020·Neuropathology and Applied Neurobiology·Gabriela CarrenoJuan Pedro Martinez-Barbera
Dec 30, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adonis SferaJose Campo Maldonado
Oct 15, 2020·International Journal of Molecular Sciences·Ruben Aquino-MartinezDavid G Monroe
Mar 11, 2021·Briefings in Functional Genomics·Ryan J LuBérénice A Benayoun
Mar 26, 2021·Innate Immunity·Arosh Shavinda Perera Molligoda Arachchige
Mar 26, 2021·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Georgia KarpathiouMichel Peoc'h
Jan 21, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Steven A Bloomer, Eric D Moyer
May 13, 2021·Nature Reviews. Clinical Oncology·Laurence ZitvogelGuido Kroemer
Jun 3, 2021·Cells·Maria Sol Jacome Burbano, Eric Gilson
Jun 3, 2021·Cells·Gabriela Rapozo GuimarãesMariana Boroni
Jun 3, 2021·Cells·Mattia GaruttiFabio Puglisi
Jun 25, 2021·Mechanisms of Ageing and Development·Chin Yee Ho, Oliver Dreesen
Jul 3, 2021·International Journal of Molecular Sciences·Harvey BougheySherif F El-Khamisy
Jul 13, 2021·Frontiers in Cellular Neuroscience·Adonis SferaZisis Kozlakidis
Jul 3, 2021·International Journal of Molecular Sciences·Tanyalak ParimonChangfu Yao
Jul 6, 2021·Frontiers in Immunology·Ross A CampbellKatie J Mylonas
Jul 25, 2021·Ageing Research Reviews·Tesfahun Dessale AdmasuAlexandra Stolzing
Aug 13, 2021·Aging·Vivekananda BudamaguntaDaohong Zhou
Aug 28, 2021·Frontiers in Immunology·Mikel Etxebeste-MitxeltorenaBeatriz Martín-Antonio
Sep 23, 2021·Cardiovascular Research·Peter Libby
Nov 12, 2021·Aging Cell·Sabira MohammedSathyaseelan S Deepa
Jan 8, 2022·Diabetes·Korbyn J V Dahlquist, Christina D Camell
Jan 21, 2022·Molecular Therapy : the Journal of the American Society of Gene Therapy·Pallavi ChaturvediHing C Wong

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Methods Mentioned

BETA
transgenic

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