PMID: 2099344Jan 1, 1990Paper

Role of immunoglobulins G1 and G2 in anaphylactic shock in the guinea pig

International Archives of Allergy and Applied Immunology
S DesquandB B Vargaftig

Abstract

Heating serum from actively sensitised guinea pigs did not remove its ability to sensitise recipient animals in vivo and parenchymal lung strips in vitro to anaphylaxis. Thermoresistant antibodies should thus account for the transferable sensitising effect, which persists for at least 9 days. IgG1 and IgG2, contained in the serum, were separated by affinity chromatography to determine the importance and the participation of these subclasses in passive anaphylactic shock. IgG1, present in smaller amounts than IgG2, was more effective in sensitising isolated lung strips. The intravenous administration of ovalbumin to guinea pigs, which had been injected with 0.8 mg/kg of IgG1 or 2 mg/kg of IgG2 9 days beforehand, induced an intense bronchoconstriction with leucopenia and moderate thrombopenia, suggesting an as yet undescribed role for IgG2 in passive tissue sensitisation. The use of mepyramine, an antagonist of the histamine H1 receptor, WEB 2086, an antagonist of platelet-activating factor, and nordihydroguaiaretic acid, a dual inhibitor of cyclooxygenase and lipooxygenase, alone or associated, demonstrated that the anaphylactic contraction of lung strips from guinea pigs sensitised by IgG1 is mediated by histamine and arachidon...Continue Reading

Citations

May 1, 1991·Medicinal Research Reviews·P BraquetM Koltai
Jul 22, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Patricia Ramos-RamírezMikael Adner
Jul 7, 1998·Toxicology and Applied Pharmacology·D G FraserJ F Regal

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.