Role of indirect allorecognition in experimental late acute rejection

Transplantation
J P VellaM H Sayegh

Abstract

Late acute rejection affects up to 28% of renal allograft recipients and remains a major risk factor for late graft loss. As donor-origin antigen-presenting cells are depleted with time, T-cell recognition of donor-derived alloantigenic peptides presented by self antigen-presenting cells (the "indirect pathway" of allorecognition) may play a key role in the initiation of late acute rejection episodes. To test this hypothesis, we developed a clinically relevant experimental model in the rat (Wistar-Furth/Lewis) in which allograft recipients received cyclosporine for 1 month after transplantation and were then allowed to reject the graft upon discontinuation of immunosuppression. Lymphocyte proliferation assays to synthetic class II MHC allopeptides of donor origin and also to intact donor (Wistar-Furth) cells were performed at this time. The effector mechanisms studied included delayed-type hypersensitivity (DTH) responses, lymphocyte-mediated cytotoxicity, and alloantibody production. Lymphocytes from recipients undergoing late acute rejection had marked suppression of mixed lymphocyte reaction proliferation to intact donor cells. Significant proliferation to donor-derived 25-mer polymorphic class II MHC allopeptides was elicit...Continue Reading

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M H SayeghC B Carpenter
May 1, 1986·European Journal of Immunology·R A SherwoodL S Rayfield
Jan 1, 1986·Annual Review of Immunology·D W Mason, P J Morris
Jun 1, 1993·The Journal of Experimental Medicine·Z LiuN Suciu-Foca
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·J M Connolly
Mar 1, 1994·The Journal of Experimental Medicine·R S LeeH Auchincloss
Dec 1, 1993·Journal of the American Society of Nephrology : JASN·D E HricikJ Herson
Jan 1, 1994·Immunology Today·D A Shoskes, K J Wood
Jan 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C E SandersA G Diethelm
Feb 1, 1996·The Journal of Experimental Medicine·D J SteeleH Auchincloss
Jan 1, 1996·International Reviews of Immunology·M H Sayegh, C B Carpenter
Sep 1, 1996·The Journal of Clinical Investigation·Z LiuN Suciu-Foca

❮ Previous
Next ❯

Citations

Dec 26, 2001·European Journal of Immunology·Ricardo Pimenta-AraujoAntonio Bandeira
Aug 17, 2002·Current Opinion in Immunology·Sita Gourishankar, Philip F Halloran
Jun 12, 2003·Transplant Immunology·Michel P M VierboomMargreet Jonker
Oct 12, 2010·The New England Journal of Medicine·Brian J Nankivell, Stephen I Alexander
Apr 20, 2002·Transplantation·Anna ValujskikhPeter S Heeger
May 30, 2013·Transplantation·Jason M AliGavin J Pettigrew
Jan 9, 2009·Journal of the American Society of Nephrology : JASN·Takuya UenoReza Abdi
Dec 17, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ronald P PelletierCharles G Orosz
Jan 19, 2006·Therapeutic Drug Monitoring·Malek Kamoun
Feb 13, 2016·Frontiers in Immunology·Michelle J HickeyElaine F Reed
Jan 1, 2008·The Journal of Surgical Research·Andrei ZdoroveacMartina Seifert
Jul 2, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kirsten A ThusEric Spierings
Apr 7, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T V BrennanS-M Kang
Mar 18, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·V CoelhoJ Kalil
Jun 2, 2016·Journal of Nephrology·Oriol Bestard, Paolo Cravedi
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K L WomerM H Sayegh
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K L WomerH Auchincloss
Apr 10, 2015·Journal of the American Society of Nephrology : JASN·Ibrahim BatalAnil Chandraker
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Syed HuqM Reza Dana
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R Pimenta-AraujoA Bandeira
Jul 5, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Philip F Halloran
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Afsaneh AmouzegarReza Dana
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Avi-Hai HovavNorman L Letvin
May 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Peter S Heeger
Jan 24, 2002·Journal of the American Society of Nephrology : JASN·Igor A LaskowskiNicholas L Tilney
Oct 25, 2001·Journal of the American Society of Nephrology : JASN·Karl L WomerMohamed H Sayegh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.