Abstract
The aim of this study was to assess the efficacy, safety and tolerability of pegylated interferon and ribavirin in HIV/hepatitis C virus (HCV)-coinfected patients, prescribed for the same duration and at the same dosage as that used in HCV monoinfection studies. It was an open-label, single-centre, prospective study. Forty-five patients coinfected with HIV and HCV with CD4 counts >200 cells/microL were treated with pegylated interferon-alpha2b 1.5 microg/kg/week and ribavirin 1000-1200 mg/day for 24-48 weeks depending on HCV genotype. Safety and tolerability were assessed weekly for the first month and monthly thereafter. Virological response was assessed at weeks 4, 12 and 24 and at the end of treatment and 12 and 24 weeks post completion of treatment. The primary endpoint was defined as undetectable HCV RNA at 24 weeks post completion of treatment [sustained virological response (SVR)]. The majority of patients were male and had been injecting drug users. Sixty per cent were on antiretroviral therapy. In an intention-to-treat analysis, 53% had an SVR (genotype 1, 19% and genotype 2/3, 75%). All patients who had undetectable HCV RNA at week 4 of HCV treatment [very early virological response (VEVR)] had a SVR. On multivariate ...Continue Reading
References
May 1, 1995·The Journal of General Virology·F DavidsonG A Medgyesi
Mar 27, 1998·The New England Journal of Medicine·F J PalellaS D Holmberg
Dec 16, 1998·Lancet·A MocroftJ D Lundgren
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I BicaD R Snydman
Jun 16, 2001·Lancet·D Salmon-CéronP Sogni
Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H K MongaB Yoffe
Oct 5, 2001·Lancet·M P MannsJ K Albrecht
Feb 8, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenneth E ShermanNatasa Rajicic
Mar 29, 2002·AIDS·Vincent SorianoJürgen Rockstroh
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Dec 3, 2002·Archives of Internal Medicine·Felicitas C KuehneSue J Goldie
Dec 20, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine A FlemingDavid Nunes
Feb 1, 2003·Annals of Internal Medicine·Mark S Sulkowski, David L Thomas
Apr 18, 2003·AIDS·Mayte Pérez-OlmedaVincent Soriano
Apr 20, 2004·AIDS·Leonor MorenoSantiago Moreno
Jul 30, 2004·The New England Journal of Medicine·Francesca J TorrianiUNKNOWN APRICOT Study Group
Jul 30, 2004·The New England Journal of Medicine·Raymond T ChungUNKNOWN AIDS Clinical Trials Group A5071 Study Team
Aug 19, 2004·AIDS·Montserrat LagunoJosep Mallolas
Nov 25, 2004·International Journal of Epidemiology·Charlotte LewdenUNKNOWN Mortality 2000 study group
Dec 4, 2004·AIDS·Maurizio BonaciniAmy Rock Wohl
Dec 16, 2004·JAMA : the Journal of the American Medical Association·Fabrice CarratUNKNOWN ANRS HCO2 RIBAVIC Study Team
Jul 14, 2005·HIV Medicine·M NelsonUNKNOWN British HIV Association
Citations
Dec 6, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Piero Luigi AlmasioFrancesca D'Angelo
Jan 20, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Robert S Brown
Aug 30, 2007·AIDS Research and Human Retroviruses·Marina NúñezUNKNOWN PRESCO Study Group
May 16, 2007·AIDS·Vincent SorianoJuergen Rockstroh
Dec 20, 2007·AIDS·Luz Martin-CarboneroVincent Soriano
Aug 13, 2009·World Journal of Gastroenterology : WJG·Ashwani-K Singal, Bhupinderjit S Anand
Sep 26, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Antonio Rivero-JuarezUNKNOWN Grupo Andaluz para el Estudio de las Hepatitis Víricas (HEPAVIR), part of the Sociedad Andaluza de Enfermedades Infecciosas
Jul 16, 2010·Expert Opinion on Pharmacotherapy·MariaCássia Mendes-Corrêa, Marina Núñez
Jan 29, 2008·Journal of Viral Hepatitis·D O SheaC Bergin
Apr 20, 2010·HIV Clinical Trials·M Rodriguez-TorresD T Dieterich
Oct 15, 2011·International Journal of STD & AIDS·J KieranC Bergin
Nov 1, 2007·Current Opinion in HIV and AIDS·Vincent SorianoPablo Barreiro
Nov 1, 2007·Current Opinion in HIV and AIDS·Marija Zeremski, Andrew H Talal
Apr 8, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ashwin BalagopalDavid L Thomas
Sep 19, 2014·World Journal of Gastroenterology : WJG·Louise Nygaard ClausenThomas Benfield
Aug 10, 2019·BMC Infectious Diseases·D CrowleyM C Van Hout