PMID: 8596542Jan 1, 1996Paper

Role of induced genetic instability in the mutagenic effects of chemicals and radiation

Mutation Research
J P Murnane

Abstract

Recent studies have demonstrated that cells exposed to ionizing radiation or alkylating agents can develop prolonged genetic instability. Induced genetic instability is manifested in multiple ways, including delayed reproductive death, an increased rate of point mutations, and an increased rate of chromosome rearrangements. In many respects these changes are similar to the genetic instability associated with cancer and some human genetic diseases. Therefore, as with cancer cells, multiple mechanisms may be involved, some occurring in the early stages and some in the later stages. The high percentage of cells that develop induced genetic instability after exposure to stress, and the prolonged period over which the instability occurs, indicates that the instability is not in response to residual damage in the DNA or mutations in specific genes. Instead, changes affecting most of the exposed cells, such as epigenetic alterations in gene expression or chain reactions of chromosome rearrangements, are a more likely explanation. Learning more about the mechanisms involved in this process is essential for understanding the consequences of exposure of cells to ionizing radiation or alkylating agents.

References

Jan 1, 1979·Cytogenetics and Cell Genetics·C L LeeO P Kamra
Oct 1, 1975·Mutation Research·A V CarranoD Piluso
Aug 19, 1992·International Journal of Cancer. Journal International Du Cancer·F HoffschirB Dutrillaux
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K A SmithG R Stark
Jun 18, 1992·Nature·L SabatierM B Martin
Jul 2, 1992·Nature·D P Lane
May 1, 1991·Cancer Genetics and Cytogenetics·T M Nicotera
Sep 1, 1991·International Journal of Radiation Biology·W P Chang, J B Little
Oct 15, 1991·Cancer Genetics and Cytogenetics·T L KojisR S Sparkes
Jul 22, 1991·FEBS Letters·J Lewis, A Bird
Feb 1, 1991·The Journal of the Association of Physicians of India·S C ParuthiH Singh
Jul 5, 1991·Science·M HollsteinC C Harris
Dec 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J P Murnane
Dec 1, 1990·International Journal of Radiation Oncology, Biology, Physics·J B LittleH Vetrovs
Feb 1, 1990·Molecular and Cellular Biology·T de LangeH E Varmus
May 31, 1990·Nature·C B HarleyC W Greider
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P A JonesS J Tapscott
Aug 30, 1990·Nature·N D HastieR C Allshire
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S Shuman
Jan 1, 1989·Experimental Gerontology·T MatsumuraR Holliday
Apr 1, 1989·International Journal of Radiation Biology·L Gorgojo, J B Little
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T D TlstyK Lum
Oct 1, 1989·Trends in Genetics : TIG·N D Hastie, R C Allshire

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Citations

Sep 5, 1998·Mutation Research·M Harms-Ringdahl
Sep 28, 1998·Mutation Research·B LambertA Wennborg
Dec 5, 1998·Mutation Research·S R BakshiU M Rawal
Aug 13, 2003·Annals of Diagnostic Pathology·Elisabeth J RushingHernando Mena
Aug 16, 2006·DNA and Cell Biology·Ranbir Chander SobtiSara Raimondi
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·P WangL F Povirk
Mar 15, 2016·Journal of Photochemistry and Photobiology. B, Biology·Amel F M Ismail, Sawsan M El-Sonbaty
Oct 11, 2011·Population and Development Review·David P BakerMarcela Movit
Dec 18, 2004·Mutation Research·Martin F LavinNuri Gueven
Apr 20, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ulko UndegerNurçen Baçaran
Dec 1, 2001·International Journal of Hygiene and Environmental Health·W W Au
Apr 18, 2016·Journal of Photochemistry and Photobiology. B, Biology·Amel F M IsmailMamdouh M T Eassawy
Jun 15, 2012·Developmental Cognitive Neuroscience·David P BakerPaul J Eslinger
Mar 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·L A RamadanO H El-Habit
Sep 28, 2004·Radiation Research·Rebecca E Rugo, Robert H Schiestl
Sep 24, 2016·International Journal of Radiation Biology·Elena Yushkova, Vladimir Zainullin
Aug 24, 1999·Journal of Occupational and Environmental Medicine·U UndeğerN Başaran
Jan 1, 1997·Radiation Oncology Investigations·R M CaronJ B Little
Dec 14, 2004·The Oncologist·Peter Vaupel
Dec 20, 2002·The Oncologist·Louis B HarrisonDaniel Shasha
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Denise Campisi HeganPeter M Glazer
Nov 21, 2018·Life Science Alliance·Monika Dudenhöffer-Pfeifer, David Bryder
Jun 11, 2009·Journal of Cellular and Molecular Medicine·Arnab PalParthaprasad Chattopadhyay
Jul 28, 2011·NMR in Biomedicine·Reut AvniMichal Neeman
Feb 5, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stephan Joel ReshkinRosa Angela Cardone
Apr 18, 2014·CPT: Pharmacometrics & Systems Pharmacology·D JayachandranD Ramkrishna
Mar 1, 2017·Molecular Pharmacology·Xin Xin XiongXiao Qian Chen

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