Role of inducible costimulator in the development of lupus in MRL/lpr mice

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Yoshifumi TadaKohei Nagasawa

Abstract

Inducible costimulator (ICOS) is a costimulatory molecule expressed in activated T cells and plays an important role in T-cell-dependent immune responses. We investigated the role of ICOS in the development of autoimmune diseases in MRL/Mpj-lpr/lpr (MRL/lpr) mice. ICOS was expressed on CD4(+) T cells from adult MRL/lpr mice. ICOS-deficient MRL/lpr mice showed mild lymphoadenopathy and a decreased memory type CD4(+) T cells in the spleen. The anti-dsDNA antibody levels were decreased. CD4(+) T cells from ICOS-deficient MRL/lpr mice showed less of a bias to Th1 and an enhanced production of IL-4 in response to anti-CD3 antibody in comparison to those from wild-type MRL/lpr mice. Although ICOS-deficiency abrogated renal vasculitis completely, the severity of glomerulonephritis was not altered. ICOS is considered to play a role in CD4(+) T cell activation, autoantibody production, and renal vasculitis. However, it is not essentially required in the development of glomerulonephritis.

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Citations

Jun 29, 2011·The Journal of Biological Chemistry·Kailin YanNilamadhab Mishra
Sep 4, 2013·Clinical & Developmental Immunology·Nien Yee Kow, Anselm Mak
Dec 18, 2013·International Immunology·Shizue Futatsugi-YumikuraTomohiro Yoshimoto
Jan 22, 2015·Arthritis Research & Therapy·Sabrina CeerazRandolph J Noelle
Feb 10, 2011·Arthritis and Rheumatism·Yoshifumi TadaKohei Nagasawa
Mar 29, 2008·Lupus·S K Datta, C Mauri
Jun 1, 2012·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Leonard H Sigal
Jan 11, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L RankinKyri Dunussi-Joannopoulos
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel HawigerRichard A Flavell
Jun 15, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nanette MitterederGianluca Carlesso

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