Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review

Mediators of Inflammation
Yue LangLi Cui

Abstract

Inflammasomes are multiprotein complexes that can sense pathogen-associated molecular patterns and damage-associated molecular signals. They are involved in the initiation and development of inflammation via activation of IL-1β and IL-18. Many recent studies suggest a strong correlation between inflammasomes and neurological diseases, such as multiple sclerosis (MS), Alzheimer's disease (AD), and Parkinson's disease (PD). Several components of inflammasomes, such as nucleotide-binding oligomerization domain- (NOD-) like receptor, absent in melanoma 2- (AIM2-) like receptors (ALRs), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1, as well as the upstream factors and downstream effectors, are associated with the initiation and development of MS and its animal model, experimental autoimmune encephalomyelitis. Additionally, inflammasomes affect the efficacy of interferon-β therapy in patients with MS. Finally, the strong association of inflammasomes with AD and PD needs to be further studied. In this review of latest literatures, we comprehensively tease out diverse roles of different kinds of inflammasomes in neuroimmune and neurodegenerative diseases, especially in the perspect...Continue Reading

References

May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G SpillantiniM Goedert
Mar 12, 1999·Annual Review of Medicine·B G Arnason
Nov 24, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·R FurlanG Martino
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·H MochizukiY Mizuno
Oct 16, 2002·Glia·Uwe-Karsten Hanisch
May 24, 2003·Vaccine·Christelle BassetIvan Roitt
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Jan 13, 2006·Nature·Sanjeev MariathasanVishva M Dixit
Sep 16, 2006·Cell Death and Differentiation·F Martinon, J Tschopp
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Azeb Tadesse ArgawGareth R John
Dec 21, 2006·Rheumatology·T LequerréX Le Loët
Mar 14, 2007·Molecular Cell·Benjamin FaustinJohn C Reed
Mar 23, 2007·Annals of the New York Academy of Sciences·Estelle Bettelli
Dec 28, 2007·Molecular and Cellular Biology·Zhengmao YeJenny P-Y Ting
Mar 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juan Pablo de Rivero VaccariRobert W Keane
Aug 2, 2008·Journal of Cellular and Molecular Medicine·Cintia RoodveldtChristopher M Dobson
Jan 23, 2009·Nature·Teresa Fernandes-AlnemriEmad S Alnemri
May 7, 2009·The Journal of Biological Chemistry·William R SilvermanGerhard Dahl
Jul 17, 2009·The Journal of Biological Chemistry·Andrea BabelovaLiliana Schaefer
Oct 16, 2009·Rheumatology·Sandrine Compeyrot-LacassagneIsabelle Koné-Paut
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Athena M SoulikaDavid Pleasure
Apr 14, 2010·The Journal of Experimental Medicine·Irving C AllenJenny P-Y Ting
Jun 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah E WarrenAlan Aderem
Jun 25, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Denis GrisJenny P-Y Ting
Feb 9, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G YahalomA Livneh
Apr 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen J LalorKingston H G Mills
Apr 16, 2011·Trends in Immunology·Jarod ZeppXiaoxia Li

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Citations

Dec 21, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kehong ChenYani He
Apr 10, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nina BoxbergerUwe K Zettl
Jun 30, 2019·Scientific Reports·Roberta MancusoMario Clerici
Aug 15, 2020·Frontiers in Integrative Neuroscience·Yadi Guan, Fang Han
Jul 13, 2019·Frontiers in Aging Neuroscience·Carolina OsorioAdonis Sfera
Mar 17, 2020·Frontiers in Cell and Developmental Biology·Huiling XiangJing Xiong
Dec 21, 2018·Frontiers in Cellular Neuroscience·Sun-Hwa Lee, Kyoungho Suk
Dec 13, 2018·Neural Regeneration Research·Sai-Nan WangHe-Zuo Lü
Jan 3, 2021·Cellular and Molecular Neurobiology·Fillipe M de AraújoMaria Trinidad Herrero
Dec 14, 2019·Molecular Immunology·Vinicius Nunes Cordeiro LealAlessandra Pontillo
Feb 16, 2021·Frontiers in Immunology·Santosh V SuryavanshiOlga Kovalchuk
Sep 18, 2020·Immunology·Falguni BaidyaPallab Bhattacharya
Apr 29, 2021·Neural Regeneration Research·Xue ZhangAn-Mu Xie
Jul 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mengsi LinJiaying Qiu

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Methods Mentioned

BETA
gene knockout

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