Role of inflammation in intrahepatic cholestasis of pregnancy

The Journal of Obstetrics and Gynaecology Research
Ebru BiberogluNuri Danisman

Abstract

Intrahepatic cholestasis of pregnancy (ICP), the most common liver disease in pregnancy, is characterized by elevated serum total bile acid and/or transaminase concentration, and pruritus. Interleukin-6 (IL-6) is a key regulator of the immune response, hematopoiesis and inflammation. We examined both IL-6 and the frequently used inflammatory marker high-sensitivity C-reactive protein (hs-CRP) at baseline in the same study population as for the primary endpoint, in order to provide a new perspective on the pathogenesis of ICP. In this controlled cross-sectional study 65 consecutive pregnant women with ICP (34 with mild and 31 with severe disease) and 40 healthy women with uncomplicated pregnancies (control group) were examined. IL-6 and hs-CRP were compared between the groups. While serum IL-6 was significantly higher in the mild ICP (P = 0.01) and severe ICP (P = 0.001) groups than in the control group, hs-CRP was similar between the groups. Interleukin-6 may have an essential role, apart from CRP, in the pathogenesis of ICP and, also, is a more sensitive marker of inflammation.

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Citations

Mar 17, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Xiang KongXiaotong Zhu
Apr 30, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vanessa PataiaCatherine Williamson
Dec 14, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nadiye KorogluDeniz Kanber Acar
Jan 29, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·İlkbal Temel YükselBaki Erdem
Jul 14, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·F BasileV Arcoraci
Nov 3, 2020·European Journal of Gastroenterology & Hepatology·Akash RoyRadha Krishna Dhiman
Jul 14, 2021·The Journal of Obstetrics and Gynaecology Research·Recep Taha AgaogluAli Turhan Caglar
Sep 18, 2021·The Journal of Obstetrics and Gynaecology Research·Hasan EroğluAykan Yücel

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