Abstract
Prediabetes includes individuals with impaired glucose metabolism, and it has been associated with various complications of diabetes mellitus (DM), including peripheral neuropathy. We aimed to investigate the associations between pro-inflammatory (TNF-α) and anti-inflammatory (IL-10) cytokines and neuropathy of very distal sensory nerves in patients with prediabetes or type 2 DM. We included 50 patients with prediabetes, 50 patients with type 2 DM, and 44 controls in the study. Plasma levels of HbA1c, TNF-α, and IL-10 were analyzed. Electrodiagnostic testing was performed on dorsal sural and medial plantar sensory nerves, which are the very distal sensory nerves of the feet. Abnormalities in nerve conduction studies (NCS) of the dorsal sural and medial plantar sensory nerves were substantially higher in patients with prediabetes or type 2 DM. In addition, plasma levels of TNF-α were significantly higher in patients with type 2 DM than in controls, whereas IL-10 levels were significantly lower in patients with both prediabetes and diabetes. However, we found no correlation between the levels of HbA1c, TNF-α, IL-10, and abnormalities in NCS of the dorsal sural or medial plantar sensory nerves in either patient group. To our knowl...Continue Reading
References
Feb 1, 1993·Diabetologia·M J YoungP H Sonksen
Aug 9, 2001·Muscle & Nerve·S P NovellaJ M Goldstein
Mar 28, 2002·Diabetes·Eric van ExelUNKNOWN Leiden 85 Plus Study
Sep 5, 2002·Muscle & Nerve·Hiroyuki NoderaDavid N Herrmann
Jan 15, 2003·Neurology·C J SumnerM Polydefkis
Jan 8, 2004·Clinical Chemistry·Wieland HoelzelUNKNOWN IFCC Working Group on HbA1c Standardization
Nov 27, 2004·Diabetes Research and Clinical Practice·M MatsudaK Kaku
Oct 14, 2005·Journal of the Peripheral Nervous System : JPNS·Kemal BalciUfuk Utku
Oct 20, 2005·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M BlüherR Paschke
May 30, 2006·Diabetes Care·A Gordon SmithJ Robinson Singleton
Jun 14, 2006·Archives of Neurology·Charlene Hoffman-SnyderE Peter Bosch
Nov 28, 2007·Diabetes Care·Dan ZieglerUNKNOWN KORA Study Group
Feb 23, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Kayihan UlucOnder Us
May 16, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sevki SahinKubilay Karsidag
Jan 26, 2010·Trends in Endocrinology and Metabolism : TEM·Marc Y DonathJan A Ehses
Jan 15, 2011·Nature Reviews. Immunology·Marc Y Donath, Steven E Shoelson
Feb 25, 2011·Diabetologia·M N PhamUNKNOWN Action LADA Study Group
Jul 2, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yasar AltunYasar Ozkul
Jul 14, 2011·Nature Reviews. Endocrinology·Nikolaos PapanasDan Ziegler
Aug 4, 2011·American Journal of Physiology. Endocrinology and Metabolism·Isamu YamakawaHiroshi Kimura
Nov 22, 2011·Diabetes Care·Sun ImGeun-Young Park
Mar 8, 2012·Nature Medicine·Olivia Osborn, Jerrold M Olefsky
Sep 18, 2013·Diabetes, Obesity & Metabolism·C HerderD M Ouwens
Dec 3, 2013·Diabetes & Metabolic Syndrome·Gauhar HussainJamal Ahmad
Oct 9, 2014·Endocrine·Martin BuysschaertJaqueline Lonier
Nov 20, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·M B SasongkoJ J Wang
Nov 21, 2014·Handbook of Clinical Neurology·Dan ZieglerJonathan E Shaw
Dec 3, 2014·Neuroscience Letters·Tao ZhuLijuan Zhang
Jan 15, 2015·Journal of Diabetes Research·I-Th LampropoulouG Efstratiadis
Citations
Feb 22, 2016·Current Diabetes Reports·Rodica Pop-BusuiEva L Feldman
Jan 7, 2016·European Journal of Endocrinology·Imke SchamarekUNKNOWN German Diabetes Study Group
Jan 23, 2016·Molecular Neurobiology·Ze-Peng MuXiao-Long Ma
Jun 28, 2016·Brain Research Bulletin·Yunliang YangTieying Song
Dec 3, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Peng LuoHaiting Xie
Jan 10, 2018·Drug Delivery and Translational Research·Armin MooranianHani Al-Salami
Feb 9, 2017·Diabetes Care·Christian HerderDan Ziegler
Sep 14, 2017·Diabetes·Xian Shuang LiuZheng Gang Zhang
Jan 11, 2020·Scientific Reports·Armin MooranianHani Al-Salami
Nov 4, 2017·Scientific Reports·Tianhua ChenHuaxiang Liu
Oct 9, 2020·BMC Endocrine Disorders·Chaolong LiuGuohui Jiang
Dec 1, 2020·Glia·Anup BhusalKyoungho Suk
Oct 23, 2020·IScience·Xiaoju XuXu Shen
Jan 30, 2021·Oral Diseases·Daniela AdamoUNKNOWN SIPMO (Italian Society of Oral Pathology, Medicine)
Mar 20, 2018·Experimental Neurology·Lucy M HinderEva L Feldman
Apr 25, 2021·Journal of Neuroimmunology·Kathleen M Hagen, Shalina S Ousman
Apr 29, 2021·Medicine·Hua XuShitao Wang
Aug 29, 2021·Pharmaceutics·Susbin Raj WagleHani Al-Salami