Role of inflammatory responses in the pathogenesis of human cerebral aneurysm

Genetics and Molecular Research : GMR
X J FanQ D Yang

Abstract

We aimed to detect expressional profiles of intracellular cell adhesion molecule-1 (ICAM-1), nuclear factor-kappa B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) in human cerebral aneurysm, in order to investigate the effect of chronic inflammation on the pathogenesis of cerebral aneurysm. Samples from 40 cases of human cerebral aneurysms diagnosed at our hospital were selected along with 20 normal cerebral artery samples. Western blotting and immunohistochemical (IHC) staining were used to reveal expressional profiles of ICAM-1 and NF-κB in the aneurysmal wall of patients and normal cerebral artery tissues. Reverse transcription (RT)-PCR was employed to detect changes in transcript levels of MCP-1 mRNA. Western blotting showed significantly higher expressions of ICAM-1 and NF-κB in patients with cerebral aneurysm compared to the normal group (P < 0.01), which was consistent with IHC staining results. RT-PCR revealed significantly higher MCP-1 transcripts in cerebral aneurysm tissues compared to the normal group (P < 0.01), in addition to a positive relationship between ICAM-1 and NF-κB expression levels. In conclusion, expression levels of ICAM-1, NF-κB, and MCP-1 in patients are significantly elevated, suggesting an...Continue Reading

Citations

Apr 17, 2016·Journal of the Neurological Sciences·Wei-Hua WangDong Guo
Apr 20, 2016·World Neurosurgery·Fatimah M AlbrekkanAzedine Medhkour
Dec 17, 2016·AJNR. American Journal of Neuroradiology·Y-Q ZhuR Kadirvel
Jul 3, 2019·Biological Reviews of the Cambridge Philosophical Society·Shruthi S RameshDhananjaya I Bhat
Jun 9, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexander H ShannonAshish K Sharma
Aug 24, 2019·Frontiers in Cardiovascular Medicine·Eveline A C GoossensA Yaël Nossent
Jul 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sirui ZhouGuy A Rouleau
Apr 3, 2021·Journal of the Neurological Sciences·Jienan WangYueqi Zhu

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