Role of inhibitory control in modulating focal seizure spread

Brain : a Journal of Neurology
Jyun-You LiouCatherine A Schevon

Abstract

Focal seizure propagation is classically thought to be spatially contiguous. However, distribution of seizures through a large-scale epileptic network has been theorized. Here, we used a multielectrode array, wide field calcium imaging, and two-photon calcium imaging to study focal seizure propagation pathways in an acute rodent neocortical 4-aminopyridine model. Although ictal neuronal bursts did not propagate beyond a 2-3-mm region, they were associated with hemisphere-wide field potential fluctuations and parvalbumin-positive interneuron activity outside the seizure focus. While bicuculline surface application enhanced contiguous seizure propagation, focal bicuculline microinjection at sites distant to the 4-aminopyridine focus resulted in epileptic network formation with maximal activity at the two foci. Our study suggests that both classical and epileptic network propagation can arise from localized inhibition defects, and that the network appearance can arise in the context of normal brain structure without requirement for pathological connectivity changes between sites.

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Citations

Jan 27, 2019·The Journal of Physiology·Neela K CodaduAndrew J Trevelyan
Aug 23, 2019·Brain : a Journal of Neurology·Jyun-You LiouTheodore H Schwartz
Oct 1, 2019·Annals of Neurology·Haiteng JiangBin He
Aug 29, 2019·Journal of Neurophysiology·Andrew K TrybaWim van Drongelen
Jul 17, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hyun-Kyoung LimMinah Suh
Jun 11, 2019·Epilepsia·Robert C WykesNeda Bernasconi
Feb 6, 2020·Frontiers in Neural Circuits·Scott RichTaufik A Valiante
Mar 5, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robyn J NovorolskyGeorge S Robertson
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Mar 23, 2019·Neurobiology of Disease·Catherine A SchevonAndrew J Trevelyan
Apr 15, 2021·Nature Communications·Isra TamimCenk Ayata
Apr 10, 2020·Seizure : the Journal of the British Epilepsy Association·Hitten P ZaveriKlaus Lehnertz
May 15, 2021·Epilepsy Currents·Kathryn A DavisCatherine A Schevon
Jun 1, 2021·Frontiers in Neurology·William J BoslTobias Loddenkemper
Dec 12, 2021·Nature Communications·Yuki BandoRafael Yuste

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