Role of injury of gastric parietal vessels by immunocomplexes in the mechanism of gastric mucosal lesion in portal hypertension with cirrhosis

Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao
C Mba Mba, Z Yang

Abstract

The present experiment employed the immunohistochemical technique and morphological observation to investigate the expression and distribution of C3, C4, IgG, IgE 5-HT in portal hypertensive pigs with pathological change of gastric mucosa and gastric parietal vessels. The wall of gastric mucosal mirco-vessels in portal hypertensive pigs had a positive or strong positive reaction of C3, C4, IgG, IgE and 5-HT with obvious injury of gastric mucosa normal pigs imparted negative or feeble positive reaction, suggesting that during portal hypertension, the gastric mucosal micro-vessels has deposit of immunocomplexes resulting in the injury of the micro-vessels. It might be a factor involved in the pathogenesis of the gastric mucosal lesion during portal hypertension with cirrhosis.

References

Jan 1, 1992·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Z YangF Z Qiu

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Citations

Nov 8, 2005·World Journal of Gastroenterology : WJG·Tao Li, Zhen Yang

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