Role of INK4a locus in normal eye development and cataract genesis

Mechanisms of Ageing and Development
Cheolho CheongHan-Woong Lee

Abstract

The murine INK4a locus encodes the critical tumor suppressor proteins, p16(INK4a) and p19(ARF). Mice lacking both p16(INK4a) and p19(ARF) (INK4a-/-) in their FVB/NJ genetic backgrounds developed cataracts and microophthalmia. Histopathologically, INK4a-/- mice showed defects in the developmental regression of the hyaloid vascular system (HVS), retinal dysplasia, and cataracts with numerous vacuolations, closely resembling human persistent hyperplastic primary vitreous (PHPV). Ocular defects, such as retinal fold and abnormal migration of lens fiber cells, were observed as early as embryonic day (E) 15.5, thereby resulting in the abnormal differentiation of the lens. We also found that ectopic expression of p16(INK4a) resulted in the induction of gammaF-crystallin, suggesting an important role of INK4a locus during mouse eye development, and also providing insights into the potential genetic basis of human cataract genesis.

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Citations

Jan 22, 2010·Journal of Genetics·Jochen Graw
Oct 10, 2008·Journal of Proteome Research·Elena AlbèDimitri T Azar
Feb 18, 2011·International Journal of Experimental Pathology·Jaehoon LeeHan-Woong Lee
Nov 22, 2017·Veterinary Pathology·Vanessa VrolykMarie-Odile Benoit-Biancamano
Jan 26, 2022·Investigative Ophthalmology & Visual Science·Dan YeJingjing Huang

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