Role of innate immune system in the pathogenesis of ankylosing spondylitis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Negar VanakiMahdi Mahmoudi

Abstract

Ankylosing Spondylitis (AS) is a debilitating rheumatic disease that gives young adults a severe form of arthritis with pain and stiffness in the axial skeleton. After the discovery of Human leukocyte antigen B27 (HLA-B27), several hypotheses have been suggested to uncover the exact etiology of AS. The tendency of HLA-B27 to form unusual structures results in recognition and activation of crucial components in innate immune system. Moreover, cellular and soluble arms of the innate response are frequently observed within the affected tissues. Genome-wide analysis has also shown the association of several innate immune-related pathways and cytokines, which act as the effective therapeutic targets in AS. Given the importance of innate immune system, we present a general overview of innate immune components and their involvement in the pathogenesis of AS. In our belief, this kind of explanation can hopefully provide new perspectives for diagnosis and treatment of these patients in the future.

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Citations

Feb 12, 2019·International Journal of Rheumatic Diseases·Maryam HemmatzadehZohreh Babaloo
Jan 24, 2019·Expert Review of Clinical Immunology·Manfred Harth, Warren R Nielson
Dec 31, 2019·International Journal of Rheumatic Diseases·Maryam AkhtariMahdi Mahmoudi
Jan 14, 2020·Immunological Reviews·Laura C CappelliErika Darrah
Jan 14, 2021·International Journal of Rheumatic Diseases·José Francisco Zambrano-ZaragozaJuan Manuel Agraz-Cibrián
Feb 8, 2021·International Journal of Rheumatic Diseases·Mehrdad EbrazehHamed Mohammadi
Mar 31, 2021·Clinical and Translational Medicine·Jing LiuJiucun Wang

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