Role of insulin-glucose infusion in outcomes after acute myocardial infarction: the diabetes and insulin-glucose infusion in acute myocardial infarction (DIGAMI) study.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Klas Malmberg

Abstract

To review the Diabetes and Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) study for findings regarding effects on morbidity and mortality. The DIGAMI trial was an intervention study that tested the hypothesis that initial intensive metabolic control by insulin-glucose infusion for at least 24 hours followed by long-term treatment with subcutaneously administered insulin improved the prognosis in patients with diabetes and acute myocardial infarction. Overall, the intensive approach reduced the long-term relative mortality (at 3.4 years of follow-up) by 25% in the insulin-treated group. Improved long-term survival was especially evident in the prestratified group of patients without prior insulin treatment, in whom the 3.4-year mortality reduction was 45%. Furthermore, a close correlation was noted between high blood glucose level at admission and mortality among the patients in the control group; this relationship was attenuated by intensive insulin treatment. The DIGAMI study supports the theory that intensive metabolic care in patients with diabetes who have had an acute myocardial infarction improves the prognosis. The study, however, could not answer whether this result was due to the initial insulin-gluco...Continue Reading

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Citations

Mar 23, 2005·Current Opinion in Pharmacology·Burton E Sobel, David J Schneider
Jul 9, 2005·Critical Care Medicine·Matthias TurinaHiram C Polk
Mar 2, 2010·Vascular Health and Risk Management·Pasquale J Palumbo, Jonathan M Wert
Jul 31, 2007·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Eva M Vivian
Feb 17, 2009·Emergency Medicine Clinics of North America·Nina T Gentile, Karen Siren
Jan 10, 2006·Critical Care Clinics·Eric S NylénRahul Khosla
Jan 13, 2005·The Journal of Pediatrics·Roberto Izquierdo
Feb 14, 2006·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Sally Inglis, Simon Stewart
Aug 21, 2020·Circulation Research·Yi HeJay W Heinecke
Sep 4, 2020·Current Drug Safety·Anna Pietraszek

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