PMID: 8938567Nov 1, 1996Paper

Role of interferon-stimulated gene ISG-15 in the interferon-omega-mediated inhibition of human immunodeficiency virus replication

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
M S Künzi, Paula M Pitha

Abstract

Interferon-alpha (IFN-alpha) inhibits human immunodeficiency virus (HIV) replication in vivo and in vitro. In this study, we show that IFN-omega (IFN-omega) is also a potent inhibitor of HIV replication in vitro and that both laboratory and primary isolates of HIV-1 are more sensitive to IFN-omega than to IFN-alpha 2. Like IFN-alpha 2, IFN-omega inhibited proviral synthesis in acutely infected cells, but in contrast to IFN-alpha 2, IFN-omega did not alter the levels of HIV-1 unspliced messages. Yet, inhibition of HIV protein synthesis was greater in IFN-omega-treated than in IFN-alpha 2-treated cells. Whereas expression of IFN-stimulated genes was transient in IFN-alpha 2-treated cells, their expression was sustained in IFN-omega-treated cells. Expression of ISG-15 in particular was higher on treatment with IFN-omega than with IFN-alpha 2. Overexpression of ISG-15 in IFN-alpha 2-treated cells mimicked the effects of IFN-omega. In untreated cells, it resulted in the trapping of HIV unspliced RNA in the nucleus and a decrease in cytoplasmic HIV transcripts and HIV protein synthesis. These findings suggest that the sustained induction of IFN-stimulated genes by IFN-omega and that of ISG-15 in particular may confer a higher therape...Continue Reading

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Citations

Oct 2, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xin ZhaoZhaoxin Zheng
Dec 31, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Dongxian Zhang, Dong-Er Zhang
Jan 2, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Seong-Heon WieChristopher H Woelk
Dec 17, 2008·Journal of Virology·Nadia V GiannakopoulosHerbert Whiting Virgin
Aug 15, 2009·Journal of Innate Immunity·Ronald N HartyAtsushi Okumura
Oct 14, 2011·Viruses·Paula M Pitha
Aug 7, 2013·Developmental and Comparative Immunology·Young-Mao ChenTzong-Yueh Chen
Jan 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Atsushi OkumuraPaula M Pitha
Mar 19, 2011·Developmental and Comparative Immunology·Eloi R VerrierPierre Boudinot
Aug 11, 2007·Cytokine & Growth Factor Reviews·Ian F Pitha-Rowe, Paula M Pitha
May 22, 2007·Gene·Christopher H WoelkSergei L Kosakovsky Pond
May 2, 2006·Blood Cells, Molecules & Diseases·Chinh T DaoDong-Er Zhang
Feb 16, 2010·Biochimica Et Biophysica Acta·Young Joo JeonChin Ha Chung
May 12, 2016·Reproduction, Fertility, and Development·Shuan ZhaoShen-Ming Zeng
Mar 13, 2017·Journal of Cell Communication and Signaling·Angeles C Tecalco Cruz, Karen Mejía-Barreto
Dec 1, 2009·Viruses·Esperanza Gómez-LucíaAna Doménech
Apr 21, 2018·Viruses·Craig MillerSue VandeWoude
Jan 13, 2018·Microbiology and Molecular Biology Reviews : MMBR·Jean-François GélinasStephen C Hyde
Jan 19, 2018·Journal of Leukocyte Biology·Dominik Hotter, Frank Kirchhoff
May 27, 2005·The Journal of Biological Chemistry·Jana NarasimhanJung-Ja P Kim
Apr 24, 2019·Journal of Cutaneous Medicine and Surgery·Fang XieHua Zhao
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jung-Hwan KimDong-Er Zhang
Dec 14, 2018·Frontiers in Microbiology·Sneh LataAkhil C Banerjea
Jan 11, 2017·Proceedings of the National Academy of Sciences of the United States of America·Shilpa S IyerBeatrice H Hahn
Jun 19, 2021·Proceedings of the National Academy of Sciences of the United States of America·Zhourui WuKeqiang Ye

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