PMID: 7538771Mar 1, 1995Paper

Role of interferons and other cytokines in the regulation of the immune response

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
F Belardelli

Abstract

Cytokines represent the major factors involved in the communication between T cells, macrophages and other immune cells in the course of an immune response to antigens and infectious agents. A number of studies on mouse and human T helper (Th) clones have recently provided extensive evidence for the existence of different activities exhibited by Th cells (called Th1 and Th2), which was apparently inferred from the profile of cytokine secretion. The Th1-type immune response is generally associated with IgG2a production and the development of cellular immunity, the Th2-type response with IgE production, eosinophils and mast cell production. This review focuses on the role of different cytokines produced by macrophages (especially interferons (IFNs), TNF-alpha, IL-10 and IL-12) or T cells (IFNs, IL-2, IL-4, IL-10, IL-13 and TGF-beta) in macrophage-T cell interactions and the cytokine relevance in the differentiation of Th cells towards the Th1 or Th2 type of immune response. Th1-derived cytokines (IFN-gamma, IL-2, TNF-alpha) favor macrophage activation, whereas the Th2 cytokines (IL-4, IL-10, IL-13) exhibit suppressive activities on macrophage functions. A key role in the differentiation towards the Th1-type response is now attrib...Continue Reading

References

Dec 1, 1977·Cellular Immunology·I Gresser
Aug 1, 1992·Cellular Immunology·M K GatelyR Chizzonite
Jun 1, 1992·Immunology Today·M Howard, A O'Garra
Jan 1, 1992·Advances in Experimental Medicine and Biology·B J NelsonC A Nacy
Dec 1, 1992·European Journal of Immunology·S P TzungS A Cohen
Jul 1, 1992·Journal of Clinical Immunology·M HowardJ de Vries
Apr 1, 1992·Current Opinion in Oncology·K Peters, G L Vejlsgaard
Jan 1, 1990·Annual Review of Biochemistry·K I AraiT Yokota
Dec 1, 1991·The Journal of Experimental Medicine·C BogdanC Nathan
Nov 1, 1991·The Journal of Experimental Medicine·F D FinkelmanW C Gause
Jan 1, 1990·Pharmacology & Therapeutics·H A Young, K J Hardy
Aug 1, 1990·AIDS Research and Human Retroviruses·H E GendelmanM S Meltzer
Apr 1, 1986·The Journal of Experimental Medicine·K InabaS Muramatsu
Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L M WahlW L Farrar
Jan 1, 1989·Annual Review of Immunology·B Beutler, A Cerami
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T M FolksA S Fauci
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PèneJ Banchereau
Nov 14, 1986·Biochemical and Biophysical Research Communications·G GarottaM Baggiolini

❮ Previous
Next ❯

Citations

Sep 1, 2001·The Journal of Gene Medicine·L AurisicchioC Traboni
Aug 13, 2011·Archives of Virology·T MüllerC Freuling
Oct 20, 2006·Apoptosis : an International Journal on Programmed Cell Death·Kashmira KulkarniThomas L Brown
Apr 20, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hekla SigmundsdóttirHelgi Valdimarsson
May 17, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jacek R Wilczyński
Mar 24, 2004·Journal of Ethnopharmacology·Eun Mi ChoiJae-Kwan Hwang
Nov 5, 1998·Veterinary Immunology and Immunopathology·A GröneW Baumgärtner
Jun 4, 1998·Journal of Neuroimmunology·G C BaldwinD P Tashkin
Apr 30, 1998·Journal of Virological Methods·V ChieuxP Wattré
Apr 1, 1997·Neurochemistry International·M EbadiN K Lassi
Dec 14, 2002·Human Immunology·Lars Rönnblom, Gunnar V Alm
Mar 20, 2002·Cytokine & Growth Factor Reviews·Filippo BelardelliJohn M Kirkwood
Mar 20, 2002·Cytokine & Growth Factor Reviews·Ion Gresser, Filippo Belardelli
Mar 30, 2002·Trends in Immunology·Filippo Belardelli, Maria Ferrantini
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Zhijun SongNiels Høiby
Oct 15, 2011·Journal of Agricultural and Food Chemistry·Haibin TongFengfuo Du
Feb 3, 2005·Nature Reviews. Drug Discovery·Curtis T KeithBrent R Stockwell
Mar 11, 2000·Acta Physiologica Scandinavica·H SugiuraH Iwata
Nov 20, 1998·Scandinavian Journal of Immunology·S R Paludan
Apr 21, 2001·Placenta·L M PostovitC H Graham
Jun 14, 2002·Mediators of Inflammation·Jacek R WilczyńskiJan Wilczyński
May 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Baoming JiangRoger I Glass
Sep 17, 2002·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Zhijun SongArsalan Kharazmi
Aug 17, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G PiazzollaS Antonaci
Aug 7, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jennifer L BrownXiao-Qiang Qin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.