Role of interleukin-10 in the lung response to silica in mice

American Journal of Respiratory Cell and Molecular Biology
François HuauxDominique Lison

Abstract

There is evidence that, following exposure to crystalline silica, the release of several proinflammatory cytokines contributes to the induction of unbalanced inflammatory reaction leading to lung fibrosis. We have examined the potential contribution of interleukin-10 (IL-10), an anti-inflammatory cytokine, in the development of silicosis. In a mouse model of inflammatory lung reaction induced by intratracheal instillation of silica (0.5 mg and 5 mg DQ12/mouse), the levels of IL-10 protein (determined by ELISA) both in cells obtained after bronchoalveolar lavage (BAL) and in lung tissue homogenates were significantly increased when compared with controls. After in vitro lipopolysaccharide (LPS) stimulation (1 microg/ml), BAL cells obtained from silica-treated animals produced significantly more IL-10 protein and mRNA than cells obtained from control animals. To examine the role of IL-10 in the lung reaction induced by silica, IL-10-deficient animals were instilled with 5 mg of silica. Twenty-four hours after treatment, the amplitude of the inflammatory response (lactate dehydrogenase [LDH], protein and number of inflammatory cells in BAL) was significantly greater in IL-10-deficient animals than in the wild type. In contrast, th...Continue Reading

References

Feb 14, 1992·Biochemical and Biophysical Research Communications·F Q CunhaF Y Liew
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·F RoussetJ Banchereau
Apr 1, 1990·American Journal of Respiratory Cell and Molecular Biology·K E DriscollG Ridder
Sep 1, 1989·The Journal of Experimental Medicine·P F PiguetP Vassalli
Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
May 1, 1983·The American Review of Respiratory Disease·D J SchrierB M McGarry
Aug 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E J Kovacs, L A DiPietro
Jun 1, 1995·The Journal of Clinical Investigation·C Zuany-AmorimM Pretolani
Nov 1, 1994·American Journal of Respiratory Cell and Molecular Biology·E CorsiniG J Rosenthal
Jan 1, 1996·Journal of Leukocyte Biology·T J StandifordR M Strieter
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G S BaroniA Benedetti

❮ Previous
Next ❯

Citations

Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H Tsukamoto
May 22, 2010·Archives of Toxicology·Shambhoo Sharan TripathiBholanath Paul
Nov 16, 2005·Comptes rendus biologies·Federica PiccioniArturo C Verrotti
Mar 27, 2001·Transplantation Proceedings·A DosanjhB Wan
Jun 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Muhammad M KarimNahum Sonenberg
Apr 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·R C DeoS K Burley
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·G Varani
Oct 27, 2007·Antioxidants & Redox Signaling·Benjamin D BringardnerClay B Marsh
Aug 24, 2006·Current Opinion in Pulmonary Medicine·J Shirine Allam, Andrew H Limper
Aug 27, 2011·American Journal of Respiratory and Critical Care Medicine·Sandra Lo ReFrançois Huaux
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·G S DavisD R Hemenway
Apr 4, 2000·American Journal of Respiratory Cell and Molecular Biology·G S DavisD R Hemenway
Apr 18, 2001·American Journal of Respiratory Cell and Molecular Biology·M ArrasD Lison
Apr 18, 2001·American Journal of Respiratory Cell and Molecular Biology·G W Hoyle, A R Brody
Jun 21, 2003·American Journal of Respiratory Cell and Molecular Biology·Masaki FujitaRobert J Mason
Feb 21, 2004·American Journal of Respiratory Cell and Molecular Biology·Virginie BarbarinFrançois Huaux
Dec 23, 2008·American Journal of Respiratory Cell and Molecular Biology·Lei SunThomas P Shanley
Oct 11, 2005·Respiratory Research·Virginie BarbarinFrancois Huaux
Jun 26, 2010·Journal of Leukocyte Biology·Celine A BeamerAndrij Holian
Sep 10, 2010·Environmental Health Perspectives·Gillian S BackusSteven R Kleeberger
Dec 8, 2004·Environmental Health Perspectives·K Murali Krishna RaoVince Castranova
May 4, 2005·Environmental Health Perspectives·K Murali Krishna RaoVal Vallyathan
Mar 4, 2014·Respiratory Physiology & Neurobiology·Mariana Nascimento MachadoWalter Araujo Zin
Jan 10, 2014·Carcinogenesis·Christian BodeDennis M Klinman
Jul 22, 2015·Inhalation Toxicology·Hajime Kawasaki
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H LouisJ Devière
Apr 4, 2015·Journal of Clinical Biochemistry and Nutrition·Yasuo ShimizuTomihiro Kamiya
Jan 29, 2008·Seminars in Arthritis and Rheumatism·Y Stephanie GuM Eric Gershwin
Mar 26, 2016·Frontiers in Immunology·Kenneth Michael Pollard
Jul 6, 2000·Cytokine·T P ShanleyA Denenberg
Nov 27, 2004·Clinics in Chest Medicine·Kevin K Brown, Ganesh Raghu
May 19, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P J Sime, K M O'Reilly
Jul 23, 2015·Mediators of Inflammation·Erna SzikszÁdám Vannay
Oct 21, 2005·Respiratory Medicine·Pelagia G TsoutsouPashalis-Adam Molyvdas
Jun 2, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Giulia GiordanoFrançois Huaux
Dec 17, 2016·Cell and Tissue Research·Lars KnudsenMatthias Ochs
Mar 21, 2017·Inhalation Toxicology·Rajendran SellamuthuPius Joseph

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.