Role of interleukin-17 in a murine community-associated methicillin-resistant Staphylococcus aureus pneumonia model

Microbes and Infection
Yasushi ShibueKazuhiro Tateda

Abstract

Interleukin (IL)-17 is a key member of the Th17 cytokines and has been reported to be involved in the pathomechanisms underlying various diseases, including infectious diseases. Infections with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) have garnered worldwide attention, and the representative USA300 strain is known to cause pneumonia in healthy people, which can be lethal. However, little is known about the role of IL-17 in CA-MRSA pneumonia. In this study, we investigated the role of IL-17 in a CA-MRSA pneumonia animal model. Mortality was higher and occurred at an earlier stage of infection in the IL-17A-knockout mice than in the wild-type (P < 0.01) and IL-17A/F-knockout mice (P < 0.05); however, no significant difference in the intrapulmonary bacterial counts was observed among the three groups of mice. Moreover, the IL-17A-knockout group showed significantly higher levels of IL-17F and granulocyte-colony stimulating factor (G-CSF) and a significantly higher neutrophil count in the bronchoalveolar lavage fluid than the other groups. These results confirmed that G-CSF expression significantly increased, and significant neutrophilic inflammation occurred under conditions of IL-17A deficiency i...Continue Reading

Citations

May 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Mark C MarchittoLloyd S Miller
Jun 3, 2021·International Journal of Molecular Sciences·Yu SawadaMotonobu Nakamura
Jun 20, 2021·The Journal of Infectious Diseases·Zhaotao LiChristopher P Montgomery

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