Role of interleukin-2 and interleukin-6 in the mitogen responsiveness of T cells from patients with 'common-variable' hypogammaglobulinaemia

Clinical and Experimental Immunology
M E NorthJ Farrant

Abstract

We have assessed the ability of interleukin-2 (IL-2) and interleukin-6 (IL-6) to augment the proliferative response of T lymphocytes from 'common-variable' hypogammaglobulinaemia (CVH) patients and from normal controls, to the mitogens phytohaemagglutinin (PHA) and OKT3. We show that with cells from the control group and from those patients whose T cells respond to PHA within the control range, both IL-2 and IL-6 will significantly augment the response to OKT3. However, in those patients with a T cell defect in which the PHA response is below the control range, neither IL-2 nor IL-6 could restore the PHA or OKT3 response to normal. Responses to IL-2 or IL-6 alone were always in or above the control range.

References

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Citations

Nov 1, 1991·Clinical and Experimental Immunology·M E NorthJ Farrant
Apr 1, 1991·Immunological Investigations·J Farrant
May 1, 1993·Clinical and Experimental Immunology·F PandolfiF Aiuti
Sep 1, 1991·Journal of Clinical Immunology·H KanekoT Orii

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