Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice

Microbes and Infection
Elisalva T GuimarãesMilena B P Soares

Abstract

The role of cytokines in Leishmania amazonensis experimental infection has not been as well studied as in Leishmania major infection model. Here we investigated the role of interleukin (IL)-4 and PGE(2) in L. amazonensis infection of susceptible BALB/c mice. IL-4 deficient (-/-) or wild-type (+/+) BALB/c mice were infected with different inocula of L. amazonensis. Two weeks after infection with 5x10(6) promastigotes/footpad, the production of interferon (IFN)-gamma upon L. amazonensis antigen stimulation was significantly higher in lymph node cell cultures of IL-4-/- mice than in IL-4+/+ mice. The levels of anti-leishmania IgG2a antibodies were also significantly higher in serum from IL-4-/- mice. In contrast, the levels of IgG1 antibodies were increased in IL-4+/+ mice and almost undetectable in IL-4-/- mice. Despite the increased Th1 response, lesions of IL-4-/- BALB/c mice progressed similarly to those of IL-4+/+ mice upon infection with the 5x10(6) inoculum. However, IL-4-/- mice developed smaller lesions upon infection with 10(5), 10(4) or 10(3) parasites than IL-4+/+ mice. The resistance of IL-4-/- correlated with higher Th1 response, compared to IL-4+/+ upon infection with 10(4)L. amazonensis. IL-4+/+ mice treated with i...Continue Reading

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Citations

Dec 15, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Luiz Felipe Domingues PasseroMárcia Dalastra Laurenti
May 21, 2009·The Journal of Antimicrobial Chemotherapy·Elisalva T GuimarãesMilena B P Soares
Mar 8, 2008·American Journal of Respiratory Cell and Molecular Biology·Carlos H SerezaniMarc Peters-Golden
Jan 4, 2013·PLoS Neglected Tropical Diseases·Agiesh Balakrishna PillaiKai Zhang
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Oct 17, 2008·Veterinary Parasitology·Bernardo Acácio Santini Pereira, Carlos Roberto Alves
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Oct 22, 2010·Autophagy·Michael DuszenkoPaul A M Michels
Sep 7, 2016·Parasites & Vectors·Mariana M ChavesRobson Coutinho-Silva
Feb 13, 2007·Memórias do Instituto Oswaldo Cruz·Roberta Olmo Pinheiro, Bartira Rossi-Bergmann
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Dec 25, 2019·Journal of Immunology Research·Áurea GabrielGabriela Santos-Gomes
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Jul 14, 2021·BMC Microbiology·Ana Patricia Cacua GélvezAna Paula Drummond Rodrigues

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