Role of interleukin-6 in elastase-induced lung inflammatory changes in mice

Experimental Lung Research
Sadatomo TasakaAkitoshi Ishizaka

Abstract

Interleukin-6 (IL-6) is known to be involved in the pathogenesis of various inflammatory diseases, but its role in the development of pulmonary emphysema remains unclear. Wild-type (WT) and IL-6-deficient mice received either phosphate-buffered saline (PBS) or porcine pancreatic elastase (PPE) intratracheally. The development of emphysema was determined by measuring the mean linear intercept (Lm). The lung specimens were also subjected to immunohistochemistry for single-stranded DNA to detect apoptotic cells. Lung mechanics and airway responsiveness to inhaled methacholine were analyzed. Bronchoalveolar lavage (BAL) fluid was subjected to evaluation of inflammatory cell accumulation and cytokine measurement. PPE treatment caused significant increases in Lm and lung compliance, which was attenuated by IL-6 deficiency. The increases in apoptotic cells in the lung were attenuated in IL-6 null mice. Airway responsiveness was not affected by PPE challenge or IL-6 deficiency. Intratracheal PPE increased the cell counts in BAL fluid throughout the observation, which was suppressed in IL-6 null mice. In BAL fluid, PPE-induced increases in the levels of macrophage inflammatory protein (MIP)-1alpha and eotaxin were mitigated by IL-6 defi...Continue Reading

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Citations

Jan 28, 2014·Respiratory Physiology & Neurobiology·Luiz Marcelo Oliveira SantosRoseli Soncini
Jan 27, 2011·Basic & Clinical Pharmacology & Toxicology·Ken-Ichiro InoueHirohisa Takano
Mar 10, 2015·International Immunopharmacology·Chiharu TabataTakashi Nakano
Jul 5, 2016·American Journal of Respiratory and Critical Care Medicine·Saleela M RuwanpuraBrendan J Jenkins
Mar 5, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shoji SuzukiTomoko Betsuyaku
Feb 7, 2017·Cell and Tissue Research·John M CraigWayne Mitzner
Mar 20, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·P Padmini S J KhedoePieter S Hiemstra
Apr 10, 2019·American Journal of Respiratory Cell and Molecular Biology·Shigen HayashiNobuyuki Hizawa
Aug 2, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nathachit LimjunyawongWayne Mitzner

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