Role of intestinal metaplasia subtyping in the risk of gastric cancer in Korea

Journal of Gastroenterology and Hepatology
Kyung P KangIn S Song

Abstract

Gastric cancer is believed to develop by a multistage process. Intestinal metaplasia (IM) is regarded as a premalignant condition; it is classified into subtypes I, II and III. The aim of this study was to evaluate whether the subtypes of IM were associated with progression to gastric cancer. The study cohort consisted of 861 subjects, categorized as controls, gastric ulcers, dysplasia and cancer. The IM was scored histologically using the Sydney classification for the antrum and the body of the stomach. The biopsies were stained with high iron diamine and alcian blue (pH 2.5) (HID-AB2.5), and the IM was subtyped as I, II or III. The proportion of IM subtypes I, II and III were 14.5%, 47.2% and 38.3% in the antrum, and 28.1%, 57.8% and 14.1% in the body of the stomach, respectively. These distributions did not show significant differences depending on disease or Helicobacter pylori positivity. In cases that were H. pylori-positive, the prevalence of IM subtype II in the cancer and dysplasia groups was higher than in the control group in the body of the stomach (P < 0.05). The proportion of IM subtype III in the antrum increased in proportion with age (P = 0.036). IM subtyping was not found to play a major role in the prediction...Continue Reading

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Citations

Feb 7, 2009·Journal of Gastroenterology and Hepatology·Junichi Akiyama, Naomi Uemura
Feb 14, 2009·Journal of Gastroenterology and Hepatology·Rita A Busuttil, Alex Boussioutas
Mar 1, 2012·Gut and Liver·Byoung Hwan LeeIn Sung Song
Nov 13, 2009·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Bita GeramizadehMarjan Rahsaz
Dec 31, 2014·Gut and Liver·Hyuk Yoon, Nayoung Kim
Jan 3, 2013·International Journal of Cancer. Journal International Du Cancer·Carlos A GonzálezPelayo Correa
Feb 24, 2010·International Journal of Cancer. Journal International Du Cancer·Carlos A GonzálezJosé Miguel Sanz-Anquela
Apr 9, 2015·Journal of Cancer Prevention·Yo Han Park, Nayoung Kim
Aug 9, 2016·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Jong-Myon Bae, Eun Hee Kim
Dec 5, 2012·The American Journal of Gastroenterology·Amnon Sonnenberg, Robert M Genta
Apr 11, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kenshi YaoHisao Tajiri
Apr 19, 2018·Arquivos De Gastroenterologia·Luiz Gonzaga Vaz CoelhoJoaquim Prado de Moraes-Filho
Oct 3, 2018·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Kichul Yoon, Nayoung Kim
Jul 26, 2018·Arquivos De Gastroenterologia·Luiz Gonzaga Vaz CoelhoJosé Vitor Zir
Dec 17, 2020·Journal of Clinical Medicine·Ana-Maria Teodora DomșaCristina Maria Borzan
May 16, 2021·Virchows Archiv : an International Journal of Pathology·Sergejs IsajevsMarcis Leja

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