Role of intestinal myofibroblasts in HIV-associated intestinal collagen deposition and immune reconstitution following combination antiretroviral therapy

AIDS
David M AsmuthDon W Powell

Abstract

To investigate the potential role of mucosal intestinal myofibroblasts (IMFs) in HIV and associated fibrosis in gut-associated lymphoid tissue. Profibrotic changes within the secondary lymphoid organs and mucosa have been implicated in failed immune reconstitution following effective combination antiretroviral therapy (cART). Microbial translocation is believed to be sustaining these systemic inflammatory pathways. IMFs are nonprofessional antigen-presenting cells with both immunoregulatory and mesenchymal functions that are ideally positioned to respond to translocating microbial antigen. Duodenal biopsies, obtained from patients naive to cART, underwent trichrome staining and were examined for tissue growth factor-beta (TGF-β) expression. Combined immunostaining and second harmonic generation analysis were used to determine IMF activation and collagen deposition. Confocal microscopy was performed to examine IMF activation and Toll-like receptor (TLR)4 expression. Finally, primary IMF cultures were stimulated with lipopolysaccharide to demonstrate the expression of the inflammatory biomarkers. The expression of the fibrosis-promoting molecule, TGF-β1, is significantly increased in duodenal biopsies from HIV patients naïve to c...Continue Reading

References

Nov 14, 1997·The American Journal of Physiology·J Chen, L J Mandel
Jul 11, 1998·Journal of Gastroenterology·R M SantosM A Zern
Dec 1, 1998·The Journal of Physiology·D W Powell
Jul 17, 1999·The American Journal of Physiology·D W PowellA B West
Aug 13, 1999·The American Journal of Physiology·D W PowellA B West
Jul 4, 2001·Annals of Internal Medicine·E L MurphyUNKNOWN Viral Activation Transfusion Study Investigators
Sep 28, 2002·AIDS·Hernan ValdezUNKNOWN AIDS Clinical Trials Group Protocol 375 Team
Jun 14, 2003·Gastroenterology·Jan-Michel OtteDaniel K Podolsky
Jul 8, 2003·The Journal of Pathology·G Gabbiani
Feb 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shan-Shan ZhanNatalie J Torok
Aug 1, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Frank J PalellaUNKNOWN HIV Outpatient Study Investigators
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jamal I SaadaDon W Powell
Nov 23, 2006·Nature Medicine·Jason M BrenchleyDaniel C Douek
Feb 15, 2007·The Journal of Investigative Dermatology·Boris Hinz
Apr 27, 2007·The New England Journal of Medicine·UNKNOWN DAD Study GroupJens D Lundgren
May 26, 2007·The American Journal of Pathology·Boris HinzGiulio Gabbiani
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irina V PinchukVictor E Reyes
Jan 3, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lisa R MetschUNKNOWN INSPIRE Study Team
Feb 12, 2008·The Journal of Infectious Diseases·Tae-Wook ChunAnthony S Fauci
Jul 5, 2008·The Journal of Infectious Diseases·Jacob EstesTimothy W Schacker
Jul 23, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jason V BakerUNKNOWN Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA)
Oct 4, 2008·AIDS·Antonella d'Arminio MonforteUNKNOWN Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group
Jan 7, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory K RobbinsUNKNOWN AIDS Clinical Trials Group 384 Team
Jan 7, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lidia GazzolaGiulia Marchetti
Jan 13, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kristen L W WaltonR Balfour Sartor
Feb 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Colleen F KelleySteven G Deeks
Apr 7, 2009·Nature Reviews. Gastroenterology & Hepatology·Florian Rieder, Claudio Fiocchi
Jul 1, 2006·Current Opinion in HIV and AIDS·Brigitte AutranChristine Katlama
Apr 22, 2009·Blood·Irini SeretiUNKNOWN ACTG 5214 Study Team
Oct 16, 2009·The New England Journal of Medicine·UNKNOWN INSIGHT-ESPRIT Study GroupD Wentworth
Jul 1, 2010·AIDS·Alba DiazUNKNOWN Study Group of Lymphoid Tissue immunopathogenesis in HIV infection
Jul 6, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenneth A LichtensteinUNKNOWN HIV Outpatient Study (HOPS) Investigators
Aug 7, 2010·Current Gastroenterology Reports·I V PinchukD W Powell
Nov 9, 2010·Annual Review of Physiology·D W PowellR C Mifflin
Jan 22, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·R C MifflinD W Powell

❮ Previous
Next ❯

Citations

Jan 6, 2016·Current Opinion in HIV and AIDS·Netanya S Utay, Peter W Hunt
Feb 9, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christopher deFilippiJanet Lo
Dec 7, 2017·Mediators of Inflammation·T SokoyaT M Rossouw

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.