Role of intra- and extracellular calcium in histamine release from rat peritoneal mast cells

Agents and Actions
F L PearceJ R White

Abstract

The present study provides evidence for a number of calcium pools important in histamine secretion from the mast cell. Firstly, calcium loosely bound to the cell membrane, and in rapid equilibrium with the extracellular environment, may be utilized for histamine release induced by most secretagogues. Secondly, all inducers are able to mobilize deeply buried or internal stores of calcium to initiate exocytosis. Finally, calcium bound to regulatory sites in the membrane may modulate the secretory process. Removal of calcium from the latter sites by brief treatment with chelating agents markedly enhances the secretory response in the absence of extracellular calcium, probably by facilitating the mobilization of bound stores of the ion. Saturation of these sites in the presence of excess calcium inhibits the release process and may restrict influx of the cation.

References

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Citations

Dec 1, 1982·Agents and Actions·R NosálK Drábiková
Apr 1, 1983·Agents and Actions·M EnnisC T Dollery
Apr 1, 1984·Agents and Actions·P T Peachell, F L Pearce
Apr 1, 1984·Agents and Actions·N Chakravarty, W J Yu
Apr 1, 1984·Agents and Actions·F L Pearce, J R White
Apr 1, 1986·Agents and Actions·N Chakravarty, W J Yu
Nov 1, 1992·Agents and Actions·D M Grassi-Kassisse, G Ribeiro-DaSilva
Apr 1, 1989·Agents and Actions·K DrábikováR Nosál
Apr 13, 1984·European Journal of Pharmacology·M H Saad, J F Burka
Jul 11, 1985·European Journal of Pharmacology·R Sagi-EisenbergR Shelly
Jan 24, 1989·European Journal of Pharmacology·M E Cantwell, J C Foreman
Aug 22, 2001·European Journal of Pharmacology·K H PehF L Pearce
May 22, 2003·International Immunopharmacology·A TrudgettM Ennis
Jul 5, 2006·Biological & Pharmaceutical Bulletin·Yun Ho ChoiChang Ho Song
Jan 1, 1984·Acta Oto-laryngologica. Supplementum·P E Alm
Aug 1, 1981·Biochemical Pharmacology·M EnnisF L Pearce
Jan 1, 1985·British Journal of Clinical Pharmacology·F L Pearce
Feb 1, 1981·British Journal of Pharmacology·F L Pearce, J R White

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