Role of intravoxel incoherent motion MRI in early assessment of the response of esophageal squamous cell carcinoma to chemoradiotherapy: A pilot study

Journal of Magnetic Resonance Imaging : JMRI
Huanhuan ZhengZhengyang Zhou

Abstract

Since definitive concurrent chemoradiotherapy (CRT) is standard therapy for inoperable esophageal squamous cell carcinoma (ESCC), early evaluation of treatment response is crucial for patients and would be useful in assessing response, especially in patients with severe side effects. To explore the feasibility of intravoxel incoherent motion (IVIM) MRI in the early assessment of treatment response to CRT. Prospective. Twenty-three inoperable ESCC patients. IVIM 3T MRI of nine b values (0, 25, 50, 75, 100, 150, 200, 500 and 800 s/mm2 ) was performed at four timepoints: pre-CRT (within 5 days before CRT), mid-CRT (2-3 weeks after the start of CRT), end-CRT (within 5 days after the end of CRT), and post-CRT (1 month after the end of CRT). IVIM-based parameters and ADC were analyzed independently by two radiologists and treatment response was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST). Analyses of variance for repeated measurements were conducted to observe dynamic changes of IVIM-based parameters (D, f, and D*) and ADC during CRT. The parameters and their change percentages (Δ%) were compared between complete response (CR) and partial response (PR) by Mann-Whitney U-test. Diagnostic performance of parame...Continue Reading

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Citations

Jun 21, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Yang ZhouZi-Xiang Kuai
Feb 23, 2019·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Hiroki KatoMasayuki Matsuo
May 1, 2020·World Journal of Gastroenterology : WJG·Zhen-Yang LiJiang-Ting Liu
May 8, 2018·Journal of Magnetic Resonance Imaging : JMRI·Shaocheng ZhuBin Song
Jun 24, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Sophie E VollenbrockAnnemarieke Bartels-Rutten
Feb 16, 2021·Frontiers in Oncology·Petra J van HoudtUulke A van der Heide
May 22, 2021·Esophagus : Official Journal of the Japan Esophageal Society·Ryoya MizumachiHisahiro Matsubara

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