Role of ion channels in heart failure and channelopathies

Biophysics Reviews
Ann-Kathrin RahmDierk Thomas

Abstract

Heart failure (HF) is a complication of multiple cardiac diseases and is characterized by impaired contractile and electric function. Patients with HF are not only limited by reduced contractile function but are also prone to life-threatening ventricular arrhythmias. HF itself leads to remodeling of ion channels, gap junctions, and intracellular calcium handling abnormalities that in combination with structural remodeling, e.g., fibrosis, produce a substrate for an arrhythmogenic disorders. Not only ventricular life-threatening arrhythmias contribute to increased morbidity and mortality but also atrial arrhythmias, especially atrial fibrillation (AF), are common in HF patients and contribute to morbidity and mortality. The distinct ion channel remodeling processes in HF and in channelopathies associated with HF will be discussed. Further basic research and clinical studies are needed to identify underlying molecular pathways of HF pathophysiology to provide the basis for improved patient care and individualized therapy based on individualized ion channel composition and remodeling.

References

May 22, 1990·The American Journal of Cardiology·J Kjekshus
Feb 1, 1995·Journal of Cardiovascular Pharmacology·H OuadidJ Nargeot
Feb 1, 1997·Journal of Molecular and Cellular Cardiology·G J RozanskiI H Zucker
Jan 1, 1997·Basic Research in Cardiology·G HasenfussH Just
Feb 13, 2001·Journal of Molecular and Cellular Cardiology·E DupontN J Severs
May 23, 2001·The Journal of Biological Chemistry·C A Ufret-VincentyL F Santana
Feb 15, 2002·Journal of Cardiovascular Electrophysiology·Steven M Pogwizd, Donald M Bers
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Gui-Rong LiStanley Nattel
May 7, 2003·Progress in Biophysics and Molecular Biology·Clive M Baumgarten, Henry F Clemo
Jul 29, 2003·Basic Research in Cardiology·Dobromir Dobrev, Ursula Ravens
Aug 23, 2003·Circulation Research·Fadi G Akar, David S Rosenbaum
Dec 17, 2003·Circulation·Ramon BrugadaCharles Antzelevitch
May 26, 2004·Circulation·Chloé BellocqArthur A M Wilde
Jun 19, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Steven Poelzing, David S Rosenbaum
Jan 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Jochen RoseGordon F Tomaselli
Mar 12, 2005·Circulation Research·Silvia G PrioriJosé Jalife
Aug 3, 2005·The Journal of Clinical Investigation·Arthur J Moss, Robert S Kass
Aug 12, 2005·Annals of the New York Academy of Sciences·Donald M Bers, Tao Guo
Sep 27, 2005·Physiological Reviews·Jeanne M Nerbonne, Robert S Kass
May 1, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Carlo Napolitano, Silvia G Priori
Jun 21, 2007·Journal of Cardiovascular Electrophysiology·Uwais MohamedSilvia G Priori
Sep 1, 2007·Journal of Cellular and Molecular Medicine·Sawa Kostin
Feb 10, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Antony J WorkmanAndrew C Rankin

❮ Previous
Next ❯

Citations

Nov 1, 2018·Journal of Cellular Physiology·Habib HaybarNajmaldin Saki
Apr 25, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Jun ChengYan Yang
Oct 28, 2019·International Journal of Molecular Sciences·Vera PaarLukas J Motloch
Dec 12, 2019·Molecular Neurobiology·Alexandre Couto E SilvaHung Wen Lin
Oct 15, 2019·Frontiers in Physiology·Laura Martinez-MateuAdemuyiwa S Aromolaran
Jun 26, 2020·Frontiers in Molecular Neuroscience·Yunus H OzekinEmily A Bates
Jan 23, 2019·Frontiers in Physiology·Alessandra AlíAdemuyiwa S Aromolaran
Jun 21, 2020·Journal of Clinical Medicine·Gianfranco PiccirilloDamiano Magrì
Jan 1, 2021·Pacing and Clinical Electrophysiology : PACE·Gianfranco PiccirilloDamiano Magrì
Jan 17, 2021·International Journal of Molecular Sciences·Min Young ParkIk Jin Yun
Nov 23, 2020·Progress in Biophysics and Molecular Biology·Callum Michael Zgierski-Johnston, Delphine Dean
Feb 17, 2021·Stem Cell Research·Anita SarafChunhui Xu
Jul 10, 2020·Toxicology Reports·Fahad A Al-AbbasiFiroz Anwar
Apr 24, 2020·Atherosclerosis·Qiang WangYongjian Yang
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena KowalskaAlicja Nowaczyk

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Arrhythmogenic Right Ventricular Dysplasia

Arrhythmogenic right ventricular dysplasia is a congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the right ventricle wall and loss of myocardial cells. Primary injuries usually are at the free wall of the right ventricular and right atria resulting in ventricular and supraventricular arrhythmias. Discover the latest research on arrhythmogenic right ventricular dysplasia here.