Role of Ion-Phospholipid Interactions in Zwitterionic Phospholipid Bilayer Ion Permeation.

The Journal of Physical Chemistry Letters
Evelyne DeplazesAlvaro Garcia

Abstract

Despite the central role of Na+ and K+ in physiological processes, it is still unclear whether they interact or alter the physical properties of simple zwitterionic phospholipid bilayers at physiologically relevant concentrations. Here we report a difference in membrane permeability between Na+ and K+, as measured with electrical impedance spectroscopy and tethered bilayer lipid membranes. We reveal that the differences in membrane permeability originate from distinct ion coordination by carbonyl oxygens at the phospholipid-water interface, altering the propensity for bilayer pore formation. Molecular dynamics simulations showed differences in the coordination of Na+ and K+ at the phospholipid-water interface of zwitterionic phospholipid bilayers. The ability of Na+ to conscript more phospholipids with a greater number of coordinating interactions causes a higher localized energy barrier for pore formation. These results provide evidence that ion-specific interactions at the phospholipid-water interface can modulate the physical properties of zwitterionic phospholipid bilayers.

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Citations

Feb 4, 2021·Soft Matter·Saffron J BryantGregory G Warr
Sep 10, 2020·The Journal of Physical Chemistry Letters·Evelyne DeplazesAlvaro Garcia
Oct 5, 2021·Physical Chemistry Chemical Physics : PCCP·Sheikh I HossainEvelyne Deplazes
Nov 17, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Evelyne DeplazesAlvaro Garcia

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