Role of iron in the pathogenesis of respiratory disease

The International Journal of Biochemistry & Cell Biology
Md Khadem AliJay C Horvat

Abstract

Iron is essential for many biological processes, however, too much or too little iron can result in a wide variety of pathological consequences, depending on the organ system, tissue or cell type affected. In order to reduce pathogenesis, iron levels are tightly controlled in throughout the body by regulatory systems that control iron absorption, systemic transport and cellular uptake and storage. Altered iron levels and/or dysregulated homeostasis have been associated with several lung diseases, including chronic obstructive pulmonary disease, lung cancer, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. However, the mechanisms that underpin these associations and whether iron plays a key role in the pathogenesis of lung disease are yet to be fully elucidated. Furthermore, in order to survive and replicate, pathogenic micro-organisms have evolved strategies to source host iron, including freeing iron from cells and proteins that store and transport iron. To counter these microbial strategies, mammals have evolved immune-mediated defence mechanisms that reduce iron availability to pathogens. This interplay between iron, infection and immunity has important ramifications for the pathogenesis and management of human res...Continue Reading

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Citations

Dec 14, 2017·Assay and Drug Development Technologies·Hermann A M Mucke
Mar 19, 2020·The European Respiratory Journal·Md Khadem AliJay C Horvat
Jun 9, 2020·The Journal of Pathology·Patricia P Ogger, Adam J Byrne
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Feb 23, 2020·The Journal of Pathology·Md Khadem AliJay C Horvat
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May 5, 2021·American Journal of Respiratory Cell and Molecular Biology·Alexandra C Brown, Jay C Horvat

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