PMID: 8589345Jan 1, 1995Paper

Role of Ito cells in the degradation of matrix in liver

Journal of Gastroenterology and Hepatology
M J Arthur

Abstract

Liver fibrosis is a dynamic process caused by changes in not only the synthesis of matrix proteins but also their degradation. Current evidence indicates that Ito cells, when activated to a myofibroblastic phenotype, play a very active role in regulating matrix degradation in liver. This is mediated via their ability to synthesize and release several members of the matrix metalloproteinase family, a class of enzymes which are responsible for degradation of matrix proteins in the extracellular space. Activated Ito cells have been demonstrated to release prostromelysin, progelatinase A and the pro-enzyme form of interstitial collagenase. In addition, these cells can express appropriate systems for cleaving pro-metalloproteinases to active forms (e.g. the plasminogen activator system, urokinase) as well as specific tissue inhibitors of the activated metalloproteinases (TIMP). In the early phases of liver injury, enzymes with the ability to degrade components of normal liver matrix are expressed (stromelysin and gelatinase A). In contrast, in the fibrotic phase of liver injury, during which fibrillar collagens accumulate, there is little (if any) expression of interstitial collagenase but marked expression of TIMP. These findings s...Continue Reading

References

Mar 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J LiC S Lieber
Jul 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L M Matrisian
Apr 1, 1992·The Journal of Pathology·S J JohnsonA D Burt
Jan 1, 1991·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H HerbstH Stein
Oct 1, 1990·Biochemical Society Transactions·G MurphyT E Hardingham
Apr 1, 1990·Trends in Genetics : TIG·L M Matrisian
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C S HEG I Goldberg
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G I GoldbergC S He
Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MilaniH Stein
Dec 1, 1987·Experimental and Molecular Pathology·R Perez-TamayoE Gonzalez
Mar 1, 1988·Journal of Cellular Physiology·E G SchuetzP S Guzelian
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S L FriedmanD M Bissell
Sep 18, 1973·Biochemical and Biophysical Research Communications·K FujiwaraS Igarashi
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W H Abelmann
Jun 1, 1994·Gut·J P Iredale, M J Arthur
Sep 1, 1993·Journal of Gastroenterology and Hepatology·D A MuzzilloT Hayakawa
Sep 17, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y MurawakiH Shima

❮ Previous
Next ❯

Citations

Jun 1, 1997·Journal of Gastroenterology·S L Friedman
Mar 7, 1998·European Journal of Pharmacology·K MurakamiT Kondo
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M T LevyM D Gorrell
May 7, 2010·The Journal of Surgical Research·Hirochika MakinoYoshihide Hayashizaki
Dec 6, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Shigenari HozawaToshifumi Hibi
Sep 4, 2007·Digestive Diseases and Sciences·Hyun Phil ShinByoung-Kuk Jang
Dec 15, 2006·World Journal of Gastroenterology : WJG·George KoliosElias Kouroumalis
Feb 24, 1999·Journal of Gastroenterology and Hepatology·Y MurawakiH Kawasaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.