Role of keratinocyte growth factor in the control of surfactant synthesis by fetal lung mesenchyme

Endocrinology
N ChellyJacques R Bourbon

Abstract

Fetal lung maturation is regulated by mesenchymal-epithelial cell communication, which plays a major role in the control of surfactant synthesis by alveolar type II cells. We have recently shown that keratinocyte growth factor (KGF), also called fibroblast growth factor-7, enhances the maturation of fetal alveolar epithelial type II cells. Here, we investigated, among the factors produced by lung mesenchyme, the part attributable to KGF in the control of surfactant synthesis. Using a KGF-neutralizing antibody, we assessed surfactant phospholipid synthesis by measuring choline incorporation into disaturated phosphatidylcholine of isolated fetal type II cells. We found that KGF accounts for about half of the stimulating activity present in fetal lung fibroblast-conditioned medium (FCM). By contrast, the use of an epidermal growth factor-neutralizing antibody did not alter the FCM-stimulating activity. To further delineate KGF properties as a mesenchymal mediator, we wondered about its possibility to relay glucocorticoid-stimulating activity on the synthesis of the phospholipid moiety of surfactant in fetal lung fibroblasts. A 24-h exposure to dexamethasone led us to detect a 50% increase in the level of KGF messenger RNA (mRNA) i...Continue Reading

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Citations

May 6, 2006·Reproductive Biology and Endocrinology : RB&E·Marc SimardYves Tremblay
Aug 7, 2007·PLoS Medicine·Olivier BoucheratJacques R Bourbon
Jun 7, 2011·Respiratory Physiology & Neurobiology·Sandra OrgeigChristopher B Daniels
Mar 2, 2016·The International Journal of Biochemistry & Cell Biology·Mandy LaubeClaire Fabian
Nov 28, 2006·International Journal of Radiation Oncology, Biology, Physics·Pelagia G Tsoutsou, Michael I Koukourakis
Apr 5, 2011·Pediatric Pulmonology·Jens GescheWolfgang Bernhard
Apr 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lorraine B Ware, Michael A Matthay
Jan 27, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·William RaoulJacques R Bourbon
Aug 9, 2016·Pediatric Research·George KingHeber C Nielsen

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