PMID: 8589336Jan 1, 1995Paper

Role of Kupffer cells in failure of fatty livers following liver transplantation and alcoholic liver injury

Journal of Gastroenterology and Hepatology
R G ThurmanJ J Lemasters

Abstract

Kupffer cells have been implicated in mechanisms of pathophysiology following liver transplantation. Recently, postoperative injury in ethanol-induced fatty liver has been evaluated because fatty livers often fail following transplantation. The low-flow, reflow liver perfusion model was used to study the role of Kupffer cells (KC) in reperfusion injury to fatty livers from rats fed a diet containing ethanol for 4-5 weeks. Treatment with GdCl3, which selectively destroys KC, decreased cell death significantly. Thus, destruction of KC minimized hepatic reperfusion injury, most likely by inhibiting free radical formation and improving microcirculation. Since it was demonstrated recently that destruction of KC prevented the hypermetabolic state observed with acute alcohol exposure, their involvement in events leading to alcohol-induced liver disease was investigated. In rats exposed to ethanol continuously via intragastric feeding for up to 4 weeks, GdCl3 treatment prevented elevation of aspartate aminotransferase (AST) and dramatically reduced the average hepatic pathological score. These results indicate that KC participate in the early phases of alcohol-induced liver injury. Endotoxaemia occurs in alcoholics and activates KC; th...Continue Reading

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Citations

Nov 20, 2004·Transplant International : Official Journal of the European Society for Organ Transplantation·Jane M KnesJames H Southard
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·B MittendorferL S Sidossis
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Nov 30, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·N MoriD N Granger

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