Role of Kv1.3 mitochondrial potassium channel in apoptotic signalling in lymphocytes

Biochimica Et Biophysica Acta
E GulbinsIldikò Szabò

Abstract

Mitochondria have been shown to play a pivotal role in apoptotic signalling in various cell types. We have recently reported that in lymphocytes the voltage-gated potassium channel Kv1.3, known to reside in the plasma membrane, is active also in the inner mitochondrial membrane. Upon induction of apoptosis, outer-membrane inserted Bax binds to and inhibits Kv1.3 resulting in hyperpolarization, an increase in reactive oxygen species production and cytochrome c release. In cells lacking Kv1.3 these events do not take place. Here, we present new data which further corroborates an important role of this channel in the sequence of events leading to Bax-induced cytochrome c release. Recombinant Kv1.3, when pre-incubated with Bax, prevents the actions of Bax at the level of mitochondria. Furthermore, we report the presence of Kv1.3 protein in mitochondria from PC3 and MCF-7 cancer cells, suggesting that this channel might play a role in the apoptotic signalling not only in lymphocytes but also in other cells.

References

Aug 1, 1984·The Journal of Experimental Medicine·K G ChandyS Gupta
Jul 17, 1995·Biochimica Et Biophysica Acta·M Zoratti, I Szabò
May 5, 1995·Biochemical and Biophysical Research Communications·A CzyzL Wojtczak
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C Deutsch, L Q Chen
Apr 12, 1996·The Journal of Biological Chemistry·K D GarlidP A Schindler
Jan 24, 1997·The Journal of Biological Chemistry·R H SpencerK G Chandy
Aug 22, 1997·The Journal of Biological Chemistry·A Quillet-MaryG Laurent
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·I SzabòF Lang
Oct 16, 1999·The EMBO Journal·L A PardoW Stühmer
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·A Lepple-WienhuesF Lang
Jul 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·E MaenoY Okada
Apr 21, 2001·The Journal of Physiology·B Nilius
Apr 27, 2001·FEBS Letters·A J KowaltowskiA E Vercesi
Jun 28, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ekhson HolmuhamedovAndre Terzic
Aug 2, 2002·Biochemical and Biophysical Research Communications·Jürgen BockErich Gulbins
Sep 26, 2003·Biochimica Et Biophysica Acta·Keith D Garlid, Petr Paucek
Mar 6, 2004·Circulation Research·Brian O'Rourke
May 4, 2004·Trends in Pharmacological Sciences·K George ChandyMichael D Cahalan
Jan 6, 2005·The Journal of Biological Chemistry·Ildikò SzabòErich Gulbins
May 28, 2005·The EMBO Journal·Matthew G AnnisDavid W Andrews
Sep 22, 2005·Physiology·Brian O'RourkeMiguel A Aon
Dec 20, 2005·The Journal of Membrane Biology·F LangS M Huber
Dec 20, 2005·The Journal of Membrane Biology·Karl Kunzelmann
Jun 20, 2006·FEBS Letters·Walter StühmerLuis A Pardo
Jun 23, 2006·European Journal of Immunology·Rüdiger ArnoldPeter H Krammer
Apr 14, 2007·Cell Death and Differentiation·M OttS Orrenius
Jun 5, 2007·The Journal of Membrane Biology·Mansoor Abdul, Naseema Hoosein
Sep 6, 2007·Drug Metabolism Reviews·Sten Orrenius
Sep 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ildikò SzabóErich Gulbins
Dec 9, 2008·The Biochemical Journal·Michael P Murphy

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Citations

Nov 18, 2011·Pflügers Archiv : European journal of physiology·Ildikò SzabòMario Zoratti
Feb 5, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Carl D Bortner, John A Cidlowski
Apr 13, 2012·EMBO Molecular Medicine·Luigi LeanzaIldikò Szabò
Jan 29, 2014·Oncogene·L LeanzaI Szabo
Dec 5, 2015·Expert Opinion on Therapeutic Targets·Mireia Pérez-VerdaguerAntonio Felipe
Jul 6, 2010·Mitochondrion·Lucia BiasuttoJiri Neuzil
Jun 24, 2010·Biochemical and Biophysical Research Communications·Piotr BednarczykBarbara Zabłocka
Mar 10, 2016·Biochimica Et Biophysica Acta·Michał LaskowskiAdam Szewczyk
Feb 18, 2015·The Journal of Membrane Biology·Justyna GąsiorowskaKrystyna Michalak
Aug 31, 2012·Cellular & Molecular Biology Letters·Justyna GąsiorowskaKrystyna Michalak
Dec 18, 2014·Biochimica Et Biophysica Acta·Nuria ComesAntonio Felipe
Dec 3, 2014·Cell Calcium·Luigi LeanzaKatrin Anne Becker
Mar 4, 2011·Journal of Veterinary Science·Soo Hwa JangSo Yeong Lee
Jun 13, 2016·European Biophysics Journal : EBJ·Roberta PeruzzoLuigi Leanza
May 16, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Vahagn OhanyanWilliam M Chilian
Oct 23, 2015·Cell Death & Disease·A ManagòI Szabò
Aug 19, 2018·The European Journal of Neuroscience·Enrico Bagnoli, Una FitzGerald
Dec 18, 2013·Nature Reviews. Cancer·Luis A Pardo, Walter Stühmer
Apr 3, 2014·Physiological Reviews·Ildiko Szabo, Mario Zoratti
Oct 16, 2019·Frontiers in Oncology·Andrzej TeisseyreKrystyna Michalak
Jul 8, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·H RafieemehrS Shahrabi
Apr 25, 2020·Journal of Biomolecular Structure & Dynamics·Qiancheng ZhengXuri Huang
Aug 23, 2020·Biomolecules·Antoni WrzosekAdam Szewczyk
Aug 14, 2020·Electromagnetic Biology and Medicine·C CecchettoS Vassanelli
Jan 14, 2021·Journal of Molecular Structure·Andrzej TeisseyreKrystyna Michalak
Apr 20, 2021·Platelets·Joy R Wright, Martyn P Mahaut-Smith
May 1, 2021·Pharmacology & Therapeutics·Vanessa ChecchettoIldiko Szabo
Jun 8, 2021·Frontiers in Pharmacology·Junda LiuBaoming Wu
Jul 21, 2021·International Journal of Molecular Sciences·Ning-Ping FooEdmund-Cheung So

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