Role of L-carnitine in apnea of prematurity: a randomized, controlled trial

Pediatrics
Jane O'DonnellKeith J Barrington

Abstract

Carnitine is thought to be a conditionally essential biological cofactor for premature infants. A preliminary study suggested that carnitine could significantly reduce apnea of prematurity. The objective of this study was to evaluate critically the role of carnitine in idiopathic apnea of prematurity and to determine whether the use of carnitine would facilitate discontinuation of mechanical ventilatory support, shorten the duration of ventilatory support, and reduce the amount of time that such infants are exposed to both mechanical ventilation and oxygen. We also wanted to determine the effects of supplemental carnitine on weight gain, time to regain birth weight, time to achieve full enteral feedings, and length of hospital stay. A prospective, randomized, blinded trial was conducted on 44 preterm infants who were from the same neonatal intensive care unit and who were < or =32 weeks' gestational age with a postnatal age <48 hours and a birth weight <1500 g and required total parenteral nutrition (TPN). Infants were randomized to receive carnitine supplementation or placebo without crossover. Carnitine-supplemented infants received 30 mg/kg/d carnitine in their TPN until the they were tolerating 120 mL/kg/d enteral feedings,...Continue Reading

References

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Citations

Aug 9, 2003·Pediatric Research·Mark S WainwrightDavid A Stumpf
Apr 29, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Sumati PandeNora V Esteban-Cruciani
Mar 3, 2004·Seminars in Pediatric Neurology·Suresh Kotagal
Jul 1, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Catherine M CrillRichard A Helms
Mar 22, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Catherine M Crill, Richard A Helms
Oct 21, 2004·The Cochrane Database of Systematic Reviews·M KumarB Paes
Feb 27, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Manoj KumarBosco Paes

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