PMID: 22355991Feb 24, 2012Paper

Role of L-carnitine in male infertility

JPMA. the Journal of the Pakistan Medical Association
Syed Danish Haseen AhmedShahid Ahsan

Abstract

To test the hypothesis that the free L-camitine helps in maintaining normal fertility. The present descriptive study was designed to show comparison of seminal free L-carnitine and sperm quality. Case controlled convenient sampling was used to assess infertile male subjects from fertile. A total of 61 adult males were selected by consent, and were categorized as fertile and infertile on the basis of history and semen analysis. Subjects were selected from Infertility Clinic, Reproductive Health Services Centre of Jinnah Postgraduate Medical Centre, Karachi. Subject's with history of pelvic surgery, or suffering from diabetes mellitus, thyroid diseases or using steroids, antihypertensives and antipsychotics drugs were excluded from the study. Groups were compared using student's t-test and p < 0.05 was considered as statistically significant. The mean values of sperm count, total motility and normal morphology of asthenospermic and oligoasthenoteratospermic were found significantly (p < 0.05) lower when compared with fertile (control). When levels of seminal free L-carnitine were compared among groups, the result showed that infertile subjects had significantly lower (P < 0.001) when compared to fertile subjects with lowest conce...Continue Reading

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