Role of lamellar body count for the prediction of neonatal respiratory distress syndrome in non-diabetic pregnant women

Archives of Gynecology and Obstetrics
Alessandro GhidiniJohn C Pezzullo

Abstract

Lamellar body count is a new and fast technique to establish the presence of fetal lung maturity. We have assessed the predictive ability of lamellar body count for neonatal respiratory distress syndrome (RDS) in a non-diabetic population. We accessed a cohort of amniocenteses in non-diabetic women from 1998 to 2002 (n=102). Neonatal RDS was defined as need for surfactant, intubation, or continuous positive airway pressure (CPAP) in the setting of chest X-ray findings consistent with RDS. The predictive ability of lamellar body count was compared with those of lecithin/sphingomyelin (L/S) ratio and presence of phosphatidylglycerol (PG) using logistic regression analysis. The optimal threshold value of lamellar body count for prediction of neonatal RDS was established with receiver operating characteristic (ROC) curve analysis. Lamellar body count ROC curve analysis identified a lamellar body count >37,000 microl(-1) as optimal diagnostic threshold for diagnosis of lung maturity, having a negative predictive value of 98%. Lamellar body count and PG, but not L/S ratio, added significantly to the prediction of RDS. Lamellar body count is a reliable predictor of fetal lung maturity in non-diabetic women and it can replace the L/S r...Continue Reading

References

Jul 1, 1976·American Journal of Obstetrics and Gynecology·M HallmanL Gluck
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Nov 8, 2002·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·A GhidiniJ C Pezzullo

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Citations

Dec 8, 2010·Biomarkers in Medicine·Van Leung-Pineda, Ann M Gronowski
Mar 14, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Anouk E BesnardBen Willem J Mol
Aug 19, 2010·American Journal of Clinical Pathology·Christina M LockwoodAnn M Gronowski
Jul 31, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·David G GrenacheAnn M Gronowski
Apr 24, 2007·Theriogenology·C CastagnettiG Mari
Jul 15, 2011·American Journal of Obstetrics and Gynecology·Beena D KamathEmily A DeFranco
Sep 5, 2006·American Journal of Obstetrics and Gynecology·Joy Y VinkCatherine Y Spong
Jun 17, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mary Beth JanickiCarolyn M Zelop
Mar 7, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Giuseppe A Marraro
Feb 27, 2015·Journal of Perinatal Medicine·Carmen BeamonRobert Strauss
Nov 25, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Davut BozkayaMurat Yurdakok

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