Role of laminin and fibronectin in selecting myogenic versus fibrogenic cells from skeletal muscle cells in vitro

Developmental Biology
U KühlK von der Mark

Abstract

Growth of embryonic skeletal muscle occurs by fusion of multinucleated myotubes with differentiated, fusion-capable myoblasts. Selective recognition seems to prevent fusion of myotubes with nonmyogenic cells such as muscle fibroblasts, endothelial cells, or nerve cells, but the nature of the signal is as yet unknown. Here we provide evidence that one of the selection mechanisms may be the enhanced affinity for laminin of myogenic cells as compared to fibrogenic cells. Growing myotubes in myoblast cultures accumulate laminin and type IV collagen on their surface in patches and strands as the first step in assembling a continuous basal lamina on mature myofibers (U. Kühl, R. Timpl, and K. von der Mark (1982), Dev. Biol. 93, 344-359). Fibronectin, on the other hand, assembles into an intercellular fibrous meshwork not associated with the free myotube surface. Over a brief time period (10-20 min) myoblasts from embryonic mouse thigh muscle adhere faster to laminin than do fibroblasts from the same tissue; these adhere faster to fibronectin. When a mixture of the cells is plated for 20 min on laminin/type IV collagen substrates, only myogenic cells adhere, giving rise to cultures with more than 90% fusion after 2 weeks; on fibronect...Continue Reading

References

Jan 1, 1976·Developmental Biology·R O HynesC J Epstein
May 1, 1978·Experimental Cell Research·M MossR J Schwartz
Jul 15, 1977·FEBS Letters·V C DuanceA J Bailey
Jan 1, 1979·The Journal of Cell Biology·J C MurrayS I Katz
Sep 1, 1979·Experimental Cell Research·T R PodleskiK M Yamada
Mar 28, 1978·Biochimica Et Biophysica Acta·W DessauH Hörmann
Dec 17, 1985·Biochimica Et Biophysica Acta·K von der Mark, U Kühl
Jan 28, 1986·Biochemistry·H K KleinmanG R Martin
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D D RobertsV Ginsburg
Jan 17, 1970·Lancet·A E McLean
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J AbbottH Holtzer
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R BrackenburyG M Edelman
Nov 1, 1982·The Journal of Cell Biology·N T NeffA F Horwitz
Mar 29, 1983·Biochemical and Biophysical Research Communications·N C RaoL A Liotta
May 1, 1983·The Journal of Cell Biology·H L Malinoff, M S Wicha
May 1, 1983·Developmental Biology·J R Sanes, J C Lawrence
Jan 1, 1983·Annual Review of Biochemistry·K M Yamada
Sep 1, 1984·Developmental Biology·M L McGarveyM Dubois-Dalcq
Jan 1, 1984·Differentiation; Research in Biological Diversity·U KühlK von der Mark
Jan 1, 1983·The Journal of Cell Biology·J R CouchmanR Timpl
Apr 1, 1984·The Journal of Cell Biology·J B McCarthy, L T Furcht
Feb 1, 1983·The Journal of Cell Biology·J M Gardner, D M Fambrough
Jun 1, 1983·Developmental Biology·T K BorgP H Lill
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J P ThieryG M Edelman
Apr 15, 1981·Developmental Biology·J SasseK von der Mark
Dec 1, 1981·Developmental Biology·M ChiquetD C Turner

❮ Previous
Next ❯

Citations

Jun 1, 1993·Pflügers Archiv : European journal of physiology·I DubusJ L Samuel
Jul 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·H H Vandenburgh, P Karlisch
Nov 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·J TurnayM A Lizarbe
Oct 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R S Hartley, Z Yablonka-Reuveni
Nov 1, 1991·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·H InoueT Hirabayashi
Jan 1, 1990·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·L Muntz
Jan 1, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·M V DodsonB D Mathison
Aug 1, 1989·The Journal of Cell Biology·S L GoodmanK von der Mark
Sep 12, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marni D BoppartStephen J Kaufman
Aug 7, 2003·Journal of Biomaterials Science. Polymer Edition·Anna Aihua LiPatricia L Chang
Mar 10, 2004·The Journal of Reproduction and Development·Kayoko IkedaHideaki Tojo
Jul 1, 1992·Journal of Periodontology·B SteffensenR J Klebe
May 3, 2014·International Journal of Molecular Medicine·Danuta JarochaMarcin Majka
Jan 1, 1991·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·H YamashitaJ Wersäll
Jan 1, 1991·Pathology, Research and Practice·M D Grounds
Jun 11, 2015·Tissue Engineering. Part C, Methods·Shiplu Roy ChowdhuryRuszymah Bt Hj Idrus
Jul 18, 2009·Stem Cells·Ashley L SiegelD D W Cornelison
Apr 24, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Naofumi YasakaTakanori Nishimura
Feb 1, 1994·Differentiation; Research in Biological Diversity·K Naumann, D Pette
May 1, 1989·Differentiation; Research in Biological Diversity·K von der Mark, M Ocalan
Oct 29, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Eunjee A LeeNathaniel S Hwang
Apr 17, 2001·Experimental Cell Research·W E Blanco-BoseH M Blau
Mar 2, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ana Sofia CachaçoSólveig Thorsteinsdóttir
Aug 1, 1988·Journal of Oral Pathology·J H Campbell, V P Terranova
Nov 12, 2015·Scientific Reports·I Ceren YasaAyse B Tekinay
Jan 1, 1987·Differentiation; Research in Biological Diversity·U Hedin, J Thyberg
Oct 31, 2017·International Journal of Molecular Sciences·Nor Kamalia ZahariShiplu Roy Chowdhury
Aug 27, 2004·American Journal of Physiology. Cell Physiology·Patrick O Mitchell, Grace K Pavlath
Nov 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J ThybergB A Bottger
Feb 14, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Anna Aihua LiPatricia L Chang
Jan 31, 2003·The Journal of Biological Chemistry·Ulrike Mayer

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