Role of late amniocentesis in the era of modern genomic technologies

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
H Daumcollaborating authors

Abstract

Traditionally, amniocentesis is performed between 17 and 23 weeks of gestation. This enables decisions regarding the course of pregnancy to be made before viability. Less frequently, amniocentesis is performed in the third trimester. Advanced genomic technologies such as chromosomal microarray analysis (CMA) provide more detailed information about the fetus compared with traditional G-banded chromosomal analysis. The aim of this study was to assess the indications for and safety of late amniocentesis, genetic-test results (especially in the context of CMA technology) and outcome of pregnancies that underwent the procedure after 24 weeks. Medical records were analyzed retrospectively of all women in whom amniocentesis was performed at a gestational age of 24 + 0 to 38 + 6 weeks, at Hadassah Medical Center, between June 2013 and March 2017. Parameters investigated included indications for late amniocentesis, complications, CMA results and pregnancy outcome. During the study period, 291 women (303 fetuses, 277 singleton and 14 twin pregnancies; in two twin pairs, one fetus was terminated before amniocentesis) underwent late amniocentesis. CMA was performed in all instances of amniocentesis. The most frequent indication was abnorma...Continue Reading

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Citations

Dec 7, 2019·Obstetrics and Gynecology·Hagit HochnerShiri Shkedi-Rafid
Nov 6, 2020·Prenatal Diagnosis·Rachel MangelsLouanne Hudgins
Nov 24, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sophia LeytesLiat Gindes
Aug 3, 2021·Frontiers in Cell and Developmental Biology·Giedrė ValiulienėRūta Navakauskienė
Jul 15, 2021·Prenatal Diagnosis·Michal MacarovShiri Shkedi-Rafid
Sep 17, 2021·Archives of Gynecology and Obstetrics·Avital WertheimerEyal Krispin

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