Role of latent feline leukemia virus infection in nonregenerative cytopenias of cats

Journal of Veterinary Internal Medicine
Bianca StützerK Hartmann

Abstract

Nonregenerative cytopenias such as nonregenerative anemia, neutropenia, and thrombocytopenia in cats with feline leukemia virus (FeLV) antigen are assumed to be caused by the underlying FeLV infection. In addition, cats with negative FeLV antigen-test results that have cytopenias of unknown etiology often are suspected to suffer from latent FeLV infection that is responsible for the nonregenerative cytopenias. The purpose of this study was to assess the role of latent FeLV infection by polymerase chain reaction (PCR) in bone marrow of cats with nonregenerative cytopenias that had negative FeLV antigen test results in blood. Thirty-seven cats were included in the patient group. Inclusion criteria were (1) nonregenerative cytopenia of unknown origin and (2) negative FeLV antigen test result. Antigenemia was determined by detection of free FeLV p27 antigen by ELISA in serum. Furthermore, 7 cats with positive antigen test results with nonregenerative cytopenia were included as control group I, and 30 cats with negative antigen test results without nonregenerative cytopenia were included as control group II. Whole blood and bone marrow samples were tested by 2 different PCR assays detecting sequences of the envelope or long terminal...Continue Reading

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Citations

Sep 2, 2011·Journal of Feline Medicine and Surgery·Julia A BeattyVanessa R Barrs
Jan 20, 2012·Journal of the American Veterinary Medical Association·Catherine FischerDorothee Bienzle
Dec 4, 2012·Viruses·Katrin Hartmann
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Aug 3, 2011·Veterinary Immunology and Immunopathology·Katrin Hartmann
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Jun 8, 2017·Journal of Feline Medicine and Surgery·Rebecca P WilkesElizabeth M Graham
Jan 10, 2020·Journal of Feline Medicine and Surgery·Susan LittleKelly St Denis
Dec 21, 2019·BMC Veterinary Research·Mehdi Abdollahi-PirbazariMohamad Zamani-Ahmadmahmudi
Aug 28, 2020·Journal of Feline Medicine and Surgery·Regina Hofmann-Lehmann, Katrin Hartmann

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