Role of leak potassium channels in pain signaling

Brain Research Bulletin
Xiang-Yao Li, Hiroki Toyoda

Abstract

Potassium (K(+)) channels are membrane proteins that allow rapid and selective flow of K(+) ions across the cell membrane, generating electrical signals in neurons. Thus, K(+) channels play a critical role in determining the neuronal excitability. Two-pore domain (K2P) "leak" K(+) channels give rise to leak K(+) currents that are responsible for the resting membrane potential and input resistance. The wide expression of leak K(+) channels in the central and peripheral nervous system suggests that these channels are critically involved in pain signaling and behavior. Indeed, it has become apparent in the past decade that the leak K(+) channels play essential roles in the development of pain. In this review, we describe evidence for the roles of TASK1, TASK3, TREK1, TREK2, TRAAK and TRESK channels in pain signaling and behavior. Furthermore, we describe the possible involvement of TASK2 and TWIK1 channels in pain.

References

Aug 4, 1998·The EMBO Journal·A J PatelM Lazdunski
Nov 13, 1998·The Journal of Biological Chemistry·R ReyesM Lazdunski
Jan 9, 1999·The Journal of Biological Chemistry·F MaingretE Honoré
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S G WaxmanJ A Black
Aug 4, 1999·Trends in Pharmacological Sciences·R M EglenA Dray
Mar 29, 2000·The Journal of Biological Chemistry·Y KimD Kim
Apr 1, 2000·The Journal of Biological Chemistry·F MaingretE Honoré
Apr 5, 2000·The Journal of Biological Chemistry·H BangD Kim
Apr 28, 2000·Pflügers Archiv : European journal of physiology·H J MeadowsC G Chapman
May 18, 2001·Trends in Neurosciences·A J Patel, E Honoré
Jun 21, 2001·Biochemical and Biophysical Research Communications·D Kim, C Gnatenco
Dec 26, 2001·The Journal of Biological Chemistry·Gábor Czirják, Péter Enyedi
Feb 9, 2002·Brain Research. Molecular Brain Research·Anja GabrielChristoph H Kindler
Feb 12, 2002·Nature Neuroscience·Félix VianaCarlos Belmonte
May 20, 2003·The Journal of Biological Chemistry·Yorikata SanoKiyoshi Furuichi
Feb 26, 2004·The Journal of Biological Chemistry·Gábor CzirjákPéter Enyedi
Mar 3, 2004·Molecular Interventions·Douglas A BaylissEdmund M Talley
Jul 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Allison P BergDouglas A Bayliss
Jan 29, 2005·The Journal of Physiology·Coeli M B LopesDiomedes E Logothetis
Jan 29, 2005·The Journal of Physiology·Dawon KangDonghee Kim
Jan 31, 2006·Physiology·Jonathan LedouxMark T Nelson
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xiangdong ChenDouglas A Bayliss
Feb 24, 2006·American Journal of Physiology. Cell Physiology·Dawon Kang, Donghee Kim
May 6, 2006·The EMBO Journal·Abdelkrim AllouiMichel Lazdunski
Aug 26, 2006·Nature Clinical Practice. Neurology·Ralf Baron
Jan 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·María Isabel NiemeyerFrancisco V Sepúlveda
Mar 22, 2007·Nature Reviews. Neuroscience·Eric Honoré
Aug 19, 2007·Cell·Sylvain FeliciangeliFlorian Lesage
Apr 10, 2008·The Journal of Biological Chemistry·Gábor CzirjákPéter Enyedi
May 27, 2008·Neuroscience Bulletin·Dong-Yue HuangQiu-Wei Fan
Oct 1, 2008·Trends in Pharmacological Sciences·Douglas A Bayliss, Paula Q Barrett
Mar 13, 2009·The EMBO Journal·Jacques NoëlMichel Lazdunski
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Guillaume SandozFlorian Lesage
Oct 20, 2009·Cell·Allan I BasbaumDavid Julius

❮ Previous
Next ❯

Citations

Feb 6, 2017·Journal of Neurophysiology·Marina CholanianRalph F Fregosi
Jul 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Clément VerkestGuillaume Sandoz
Jun 9, 2020·Frontiers in Pharmacology·Eden AraziNoam Zilberberg
May 30, 2019·International Journal of Molecular Sciences·Isabella SalzerStefan Boehm
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·David RamírezWendy González

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.