Role of leptin G-2548A polymorphism in age- and gender-specific development of obesity

Journal of Biosciences
Adeela ShahidShahid Saeed

Abstract

Leptin is involved in the regulation of food intake and energy expenditure, and therefore, is central to adipositysensing pathway. We examined the relationship of the leptin G-2548A polymorphism with obesity and obesityrelated anthropometric and metabolic parameters in a total of 394 (239 obese and 155 non-obese) subjects between 5 and 45 years of age. Body weight, height, waist circumference (WC), hip circumference (HC) and blood pressure (BP) were measured. Body mass index (BMI) and waist-to-hip ratio (WHR) were calculated. Levels of fasting blood glucose (FBG), insulin, leptin and leptin receptor were determined, and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The LEP G-2548A polymorphism showed association with obesity in children and adolescents (less than or equal to 18 years of age) but not in adults. However, analysis by gender stratification revealed association with obesity in girls only. In addition, G-2548A polymorphism showed association with BMI, WC, HC, fasting blood glucose and serum leptin levels. This suggests that G-2548A polymorphism may influence the susceptibility to...Continue Reading

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Citations

Nov 1, 2018·PloS One·Kelsey A ChunPolly A Newcomb
May 19, 2020·Upsala Journal of Medical Sciences·Sobia Rana, Maha Mobin
Oct 6, 2016·Frontiers in Genetics·Otto K-W Cheung, Alfred S-L Cheng
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Aug 20, 2018·Current Diabetes Reports·Una FairbrotherAndrew Walley
Aug 31, 2019·Eating and Weight Disorders : EWD·Sobia Rana, Adil Anwar Bhatti
Apr 5, 2021·Endocrinología, Diabetes Y Nutrición·Astrid Selene Espinoza GarcíaZyanya Reyes Castillo
Jul 3, 2021·International Journal of Molecular Sciences·Valentina Annamaria GenchiSebastio Perrini

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