Role of leukotrienes on protozoan and helminth infections.

Mediators of Inflammation
Alexandre P Rogerio, F F Anibal

Abstract

Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities. Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated with increased mortality and impaired clearance of bacteria, fungi, and parasites. LTs play a role in the control of helminth and protozoan infections by modulating the immune system and/or through direct cytotoxicity to parasites; however, LTs may also be associated with pathogenesis, such as in cerebral malaria and schistosomal granuloma. Interestingly, some proteins from the saliva of insect vectors that transmit protozoans and secreted protein from helminth could bind LTs and may consequently modulate the course of infection or pathogenesis. In addition, the decreased production of LTs in immunocompromised individuals might modulate the pathophysiology of helminth and protozoan infections. Herein, in this paper, we showed the immunomodulatory and pathogenic roles of LTs during the helminth and protozoan infections.

References

Dec 3, 1992·The New England Journal of Medicine·S B Porter, M A Sande
Jan 1, 1992·Journal of Molecular and Cellular Cardiology·G GorelikL Sterin-Borda
Feb 1, 1989·The American Journal of Tropical Medicine and Hygiene·P F WellerJ J Jaffe
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G E GrauP Vassalli
Apr 1, 1985·Molecular and Biochemical Parasitology·J J Wirth, F Kierszenbaum
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R M LocksleyW R Henderson
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K FuruichiC Isersky
Jan 1, 1984·Annual Review of Immunology·G J Gleich, D A Loegering
Jun 1, 1995·International Journal of Immunopharmacology·F ArcoleoE Cillari
Feb 1, 1995·Annals of Tropical Medicine and Parasitology·M F Shaio, P R Lin
Jan 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·E MapabaL Rombo
Oct 1, 1993·European Journal of Immunology·K A Yamaoka, J P Kolb
Jun 22, 1996·Lancet·M EnglishK Marsh
May 21, 1998·The Journal of Infectious Diseases·W R Henderson, E Y Chi
May 29, 1998·The New England Journal of Medicine·M E Rothenberg
Dec 5, 1998·Mediators of Inflammation·L H FaccioliB B Vargaftig
May 29, 1999·The American Journal of Tropical Medicine and Hygiene·L XiaoA A Lal
Jul 15, 1999·International Journal for Parasitology·S F AliA Daugschies
Aug 24, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Moqbel, P Lacy
Apr 13, 2000·Chemical Immunology·P Lacy, R Moqbel
Nov 18, 2000·Chest·K S Babu, S S Salvi
Apr 25, 2001·The Journal of Parasitology·H L Smith, T V Rajan
Apr 10, 2002·The Journal of Allergy and Clinical Immunology·Makoto NagataYoshio Sakamoto
Aug 27, 2002·Annual Review of Entomology·Jose M C Ribeiro, Ivo M B Francischetti

❮ Previous
Next ❯

Citations

Apr 2, 2014·Veterinary Parasitology·Roberto Giacominelli-StufflerMauro Maccarrone
Mar 2, 2016·European Journal of Pharmacology·Haline OgataAlexandre de Paula Rogério
Oct 13, 2015·International Journal of Medical Microbiology : IJMM·Gabriel CabreraMarina S Palermo
Aug 29, 2014·Mediators of Inflammation·Adriana M C CanavaciAuro Nomizo
Jun 6, 2016·Experimental Parasitology·Gabriel Toffoli da SilvaFabiani Gai Frantz
Aug 4, 2016·Brain, Behavior, and Immunity·Eduardo RoggeroAdriana Del Rey
Feb 6, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Geena Mariya Jose, G Muraleedhara Kurup
Mar 27, 2013·International Journal of Molecular Sciences·David KeinanOlga J Baker
Feb 16, 2018·Frontiers in Immunology·Joice Margareth de Almeida RodolphoFernanda de Freitas Anibal
Jan 13, 2018·The Korean Journal of Parasitology·José Luis Muñoz-CarrilloMaría Alejandra Moreno-García
Dec 18, 2013·The American Journal of Tropical Medicine and Hygiene·Parminder S SuchdevLeAnne M Fox
Sep 14, 2019·The American Journal of Tropical Medicine and Hygiene·Sarit CharuchaibovornSurang Nuchprayoon
Jul 1, 2020·International Journal of Molecular Sciences·Adriana R SilvaCassiano F Gonçalves-de-Albuquerque
Nov 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ana Carolina Guerta SalinaC Henrique Serezani
Oct 16, 2021·Parasites & Vectors·Sarina KoehlerGerhard Breves

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Related Papers

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Alexandre P RogerioLúcia Helena Faccioli
Scandinavian Journal of Immunology
F F AnibalLúcia Helena Faccioli
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Alexandre P RogerioJoão B Calixto
© 2021 Meta ULC. All rights reserved