PMID: 375751Jun 1, 1979Paper

Role of ligandin in transfer of bilirubin from plasma into liver

The American Journal of Physiology
A W WolkoffI M Arias

Abstract

Multiple-indicator dilution studies of labeled bilirubin uptake were carried out on isolated perfused rat livers with variable ligandin concentrations (from normal and thyroidectomized animals with and without phenobarbital pretreatment). Ligandin concentrations, measured immunologically, increased 25% after thyroidectomy and approximately doubled after phenobarbital pretreatment but decreased to normal during perfusion in the thyroidectomized nonpretreated group. A distributed two-compartment model was fitted to the dilution data and estimates of influx, efflux, and sequestration coefficients were obtained. Influx and sequestration coefficients did not vary significantly between the groups. Efflux coefficients were significantly smaller (P less than 0.001), and hepatic ligandin concentrations were significantly larger (p less than 0.001) in phenobarbital-treated rats than in other groups. The efflux coefficient varied inversely with ligandin concentration and the volume of distribution in tissue, as perceived from the plasma space, increased in proportion to the concentration of ligandin. The increased net uptake of tracer bilirubin by the liver of phenobarbital-pretreated animals is due to decreased tracer efflux secondary to...Continue Reading

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·I ListowskyI M Arias
Jan 1, 1978·The Journal of Clinical Investigation·A W WolkoffW B Jakoby
Nov 1, 1975·The Journal of Clinical Investigation·B F ScharschmidtP D Berk
Jan 1, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·R HerzG Paumgartner
May 1, 1973·The Journal of Clinical Investigation·C A GoreskyB E Nadeau
Mar 1, 1972·The Journal of Clinical Investigation·G FleischnerI M Arias
Feb 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·D Bratlid
Aug 1, 1973·The American Journal of Physiology·J L Barnhart, R Clarenburg
Mar 17, 1973·British Medical Journal·R D Hesch, D Evered
Jul 1, 1965·Biophysical Journal·M Silverman, C A Goresky
Feb 1, 1974·The Journal of Clinical Investigation·C A Goresky, B E Nadeau
Jan 1, 1955·The Journal of Clinical Investigation·A KARMENJ S LADUE

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